Eosinophilic esophagitis; An updated review; [Œsophagite à éosinophiles ; une revue actualisée]

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Guda M.; Almagrabi A.; Zahri M.; Alshaikh N.A.; Ghoneem E.

Journal: Nutrition Clinique et Metabolisme

Publisher: Elsevier Masson s.r.l.

Publication Date: March 2026

Volume / Issue: Volume 40 / Issue 1

Article No.: 103023

ISSN: 9850562

DOI: 10.1016/j.nupar.2025.12.002

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Guda M., Gastroenterology Department, Theodore Bilharz Research institute, Giza, Egypt; Almagrabi A., Internal Medicine Department, Faculty of Medicine, Umm Alqura University, Makkah, Saudi Arabia, Almouwasat hospital, Dammam, Saudi Arabia; Zahri M., Mouwasat Hospital Khobar, Saudi Arabia, Tropical Medicine Department, Faculty of Medicine, Cairo University, Egypt; Alshaikh N.A., Mouwasat Hospital Khobar, Saudi Arabia; Ghoneem E., King Fahad Specialist Hospital, Dammam, Saudi Arabia, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Abstract

Chronic inflammatory esophageal illness, also known as eosinophilic esophagitis (EoE), is mostly caused by immunological responses mediated by T-helper 2 (Th2) cells. Dysphagia, chest pain, and regurgitation are some of the symptoms that can be seen in both adults and children. Specific histological criteria usually lead to a diagnosis of the condition, which is marked by eosinophilic infiltration of the esophagus. It is more common in men, and the incidence and prevalence of EoE are on the rise, especially in high-income nations. The etiology of EoE is influenced by both hereditary and environmental factors. In order to manage EoE effectively, it is necessary to deal with the inflammatory and fibrostenotic components of the condition simultaneously. Efficacious dietary elimination programs, such as the 6-food elimination diet (6FED), are currently being used as therapies, along with proton pump inhibitors (PPIs) and topical corticosteroids. Dupilumab and other monoclonal antibodies that target the interleukin-4 receptor alpha are examples of biologic therapeutics that are showing promise as treatments, especially for patients who have not responded to conventional methods. Nevertheless, studies are still being conducted to determine the medicines’ long-term safety and effectiveness in various patient populations. © 2025 Société francophone nutrition clinique et métabolisme (SFNCM).

Keywords

6-food elimination diet; Eosinophilic esophagitis; Proton pump inhibitors; T-Helper 2; corticosteroid; dupilumab; interleukin 4 receptor alpha; omeprazole; proton pump inhibitor; steroid; Article; blood flow; environmental factor; esophagus pH; food intake; highest income group; human; immune response; onset age; prevalence; six food elimination diet; Th2 cell; treatment response

Citation Information

Scopus Citations: 0

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