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Showing posts from February, 2019

The impact of cinnarizine and griseofulvin on juvenile and adult stages of Schistosoma mansoni

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Bibliographic Information Authors: Sarhan R.M.; Thabet H.S.; Nazeer J.T.; William S. Journal: Journal of Helminthology Publisher: Cambridge University Press Publication Date: 26 February 2019 Volume / Issue: Volume 94 Article No.: e41 ISSN: 0022149X DOI: 10.1017/S0022149X19000178 Scopus: View on Scopus PubMed: 30803454 Document Type: Article Authors and Affiliations Sarhan R.M., Faculty of Medicine, Ain Shams University, Cairo, Egypt; Thabet H.S., Faculty of Medicine, Ain Shams University, Cairo, Egypt; Nazeer J.T., Faculty of Medicine, Ain Shams University, Cairo, Egypt; William S., Theodor Bilharz Research Institute, Giza, Egypt Abstract Schistosomiasis affects millions globally. There is no vaccine, and treatment depends entirely on praziquantel (PZQ). Field isolates exhibit reduced susceptibility to PZQ, and resistance has been experimentally induced, suggesting that reliance on a single treatment is particularly dangerous. The present study investigat...

LC-MS-based metabolomic profiling of Lepidium coronopus water extract, anti-inflammatory and analgesic activities, and chemosystematic significance

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Bibliographic Information Authors: Elkhateeb A.; El-Shabrawy M.; Abdel-Rahman R.F.; Marzouk M.M.; El-Desoky A.H.; Abdel-Hameed E.-S.S.; Hussein S.R. Journal: Medicinal Chemistry Research Publisher: Birkhauser Boston Publication Date: 14 February 2019 Volume / Issue: Volume 28 / Issue 4 Pages: 505–514 ISSN: 10542523 DOI: 10.1007/s00044-019-02309-5 Scopus: View on Scopus Document Type: Article Authors and Affiliations Elkhateeb A., Phytochemistry and Plant Systematics Department, National Research Centre, 33 El Buhouth Street, Dokki, Giza, 12622, Egypt; El-Shabrawy M., Phytochemistry and Plant Systematics Department, National Research Centre, 33 El Buhouth Street, Dokki, Giza, 12622, Egypt; Abdel-Rahman R.F., Department of Pharmacology, National Research Centre, 33 El Buhouth Street, Dokki, Giza, 12622, Egypt; Marzouk M.M., Phytochemistry and Plant Systematics Department, National Research Centre, 33 El Buhouth Street, Dokki, Giza, 12622, Egypt; El-Desoky A.H., P...

A promising nystatin nanocapsular hydrogel as an antifungal polymeric carrier for the treatment of topical candidiasis

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Bibliographic Information Authors: AbouSamra M.M.; Basha M.; Awad G.E.A.; Mansy S.S. Journal: Journal of Drug Delivery Science and Technology Publisher: Editions de Sante Publication Date: February 2019 Volume / Issue: Volume 49 Pages: 365–374 ISSN: 17732247 DOI: 10.1016/j.jddst.2018.12.014 Scopus: View on Scopus Document Type: Article Authors and Affiliations AbouSamra M.M., Pharmaceutical Technology Department, National Research Centre, Cairo, 12622, Egypt; Basha M., Pharmaceutical Technology Department, National Research Centre, Cairo, 12622, Egypt; Awad G.E.A., Chemistry of Natural and Microbial Product Department, National Research Centre, Cairo, 12622, Egypt; Mansy S.S., Electron Microscopy Research Department, Theodor Bilharz Research Institute, Cairo, Egypt Abstract The objective of the present work was the development and evaluation of nystatin (Nys) nanocapsular hydrogel, as an attractive dosage form for treatment of topical candidiasis. The nanoca...

Olmesartan ameliorates chemically-induced ulcerative colitis in rats via modulating NFκB and Nrf-2/HO-1 signaling crosstalk

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Bibliographic Information Authors: Saber S.; Khalil R.M.; Abdo W.S.; Nassif D.; El-Ahwany E. Journal: Toxicology and Applied Pharmacology Publisher: Academic Press Inc. Publication Date: February 2019 Volume / Issue: Volume 364 Pages: 120–132 ISSN: 0041008X DOI: 10.1016/j.taap.2018.12.020 Scopus: View on Scopus PubMed: 30594690 Document Type: Article Authors and Affiliations Saber S., Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa City, Mansoura, Dakahlia, Egypt; Khalil R.M., Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa City, Mansoura, Dakahlia, Egypt; Abdo W.S., Department of Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt; Nassif D., Department of Pharmacy Practice, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa City, Mansoura, Dakahlia, Egypt; El-Ahwany E., Department of Immunology, ...