Nanoparticles in Wound Healing: Classification, Recent Advances, and Limitations

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Elmotazbellah M.; Soliman M.A.; El-Ghany M.N.A.; Shemis M.A.; Elzayat E.M.; Hassan N.

Journal: Regenerative Engineering and Translational Medicine

Publisher: Springer Science and Business Media Deutschland GmbH

Publication Date: 8 December 2025

ISSN: 23644133

DOI: 10.1007/s40883-025-00513-x

Scopus: View on Scopus

Document Type: Review

Authors and Affiliations

Elmotazbellah M., Biotechnology Department, Faculty of Science, Cairo University, Giza, Egypt; Soliman M.A., Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt; El-Ghany M.N.A., Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt; Shemis M.A., Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt, Biochemistry and Molecular Biology Department, Nanobiotechnology Unit, Theodor Bilharz Research Institute, Giza, Egypt; Elzayat E.M., Biotechnology Department, Faculty of Science, Cairo University, Giza, Egypt; Hassan N., Biotechnology Department, Faculty of Science, Cairo University, Giza, Egypt

Abstract

Wound healing is a complex biological process involving coordinated interactions between cells, growth factors, cytokines, and extracellular matrix components. Any disruption or delay in this process can lead to chronic or nonhealing wounds, posing significant clinical challenges. Nanomaterials have emerged as promising tools to enhance wound healing due to their unique properties, such as deep tissue penetration and controlled bioactive agent delivery. Nanoparticles have gained attention for their ability to promote angiogenesis, stimulate cellular activity, reduce inflammation, and accelerate tissue regeneration. This review provides an overview of recent advances in nanoparticle applications for wound healing, beginning with a discussion of conventional techniques and their limitations. We then explore different classes of nanoparticles—including organic, inorganic, and carbon-based nanomaterials—evaluating their mechanisms, efficacy, and drawbacks in wound repair. Key challenges such as reproducibility, toxicity, and sterility are also addressed. By synthesizing current research, this review aims to guide future developments in nanoparticle-based therapies for improved wound management and clinical translation. © The Author(s), under exclusive licence to The Regenerative Engineering Society 2025.

Keywords

carbon; growth factor; nanomaterial; nanoparticle; angiogenesis; classification; extracellular matrix; human; inflammation; nonhuman; pharmaceutics; pharmacology; reproducibility; review; tissue regeneration; wound healing

Citation Information

Scopus Citations: 1

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