Assessment of Chamomile Methanolic Extracts on the Adult and Larval Stages of Trichinella spiralis Infection in Mice

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Rashed A.A.; Kamel R.O.A.; Osman E.E.A.; Shalash I.R.; Mohamed W.A.

Journal: Journal of Scientific Research in Science

Publisher: Ain Shams University, Faculty of Women for Arts, Science & Education

Publication Date: 1 December 2025

Volume / Issue: Volume 42 / Issue 2

Pages: 562–587

ISSN: 23568364

DOI: 10.21608/jsrs.2025.427754.1237

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Rashed A.A., Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, 11757, Egypt; Kamel R.O.A., Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, 11757, Egypt; Osman E.E.A., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornaish El-Nile St, Giza, 12411, Egypt; Shalash I.R., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornaish El-Nile St, Giza, 12411, Egypt; Mohamed W.A., Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, 11757, Egypt

Abstract

The present study investigated a natural alternative treatment against T. spiralis using a methanolic extract of Matricaria recutita (chamomile). Seven groups of Swiss albino mice (CD-1) were divided into: four groups were infected and treated with chamomile extract, one group was infected and treated with albendazole, one group was infected with T. spiralis, and the last group served as a normal control. Compared to the infected untreated group, all treated groups showed a substantial decrease in the mean number of adult worms and larvae (p < 0.001). In group III (albendazole), the number of adult worms was reduced by 92.1%, whereas in group V (n-hexane), the reduction was 69%. Group III had the highest efficacy (88.3%) in reducing the larval count, followed by group V (75.3%). Group VI (ethyl acetate) had the lowest efficacy (32.2%). TNF-α and IL-10 levels in the serum of mice sacrificed at 7th and 40th dpi showed a decrease in comparison to the infected untreated group, as confirmed by biochemical investigations. The n-hexane extract of chamomile showed significant anthelmintic properties against T-spiralis, positioning it as a promising natural, affordable, and low-risk therapeutic alternative. © 2025, Ain Shams University, Faculty of Women for Arts, Science & Education. All rights reserved.

Keywords

chamomile extract; IL-10; n-hexane; TNF-α; trichinosis

Citation Information

Scopus Citations: 1

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