Association of interleukin-6 and TNF-α genetic variants with pneumonia-induced sepsis in ICU adult patients

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Khanany F.M.; Mahrose H.K.A.; El Maghraby A.M.A.; Abbas R.M.; Shata A.K.; Madbouly M.; Mahmoud M.M.; Mabrouk K.; Osman E.A.

Journal: Microbes and Infectious Diseases

Publisher: Zagazig University, Faculty of Medicine

Publication Date: 29 July 2025

Volume / Issue: Volume 7 / Issue 4

Pages: 4119–4129

ISSN: 26824132

DOI: 10.21608/mid.2025.383648.2779

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Khanany F.M., Clinical Chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt; Mahrose H.K.A., Clinical Chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt; El Maghraby A.M.A., Intensive Care Department, Theodor Bilharz Research Institute, Giza, Egypt; Abbas R.M., Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Shata A.K., Chest Department Faculty of Medicine, Ain Shams University, Cairo, Egypt; Madbouly M., Radiology Department, Theodor Bilharz Research Institute, Giza, Egypt; Mahmoud M.M., Chest Department Faculty of Medicine, Ain Shams University, Cairo, Egypt; Mabrouk K., Clinical Chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt; Osman E.A., Clinical Chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Background: Pneumonia-induced sepsis and septic shock are major global reasons for mortality. A cytokine storm, characterized by enormously elevated circulating cytokines in response to infection, involves various cytokines, such as interleukin-6 (IL-6) along with tumor necrosis factor-alpha (TNF-α), which are essential in the pathogenesis of this condition. Genetic polymorphisms have been linked to variations in producing these cytokines. Aim: We evaluated the influence of genetic variations TNF-α rs361525 and TNF-α rs1800750, together with IL-6 rs1800795 and IL-6 rs1800796, on pneumonia-induced sepsis and septic shock. Methods: This case-control research assessed genetic variation in TNF-α and IL-6 by the TaqMan real-time polymerase chain reaction in a cohort of 316 cases. 90 patients (28.5%) were diagnosed with pneumonia-induced sepsis, 60 patients (18.9%) with pneumonia-induced septic shock, and 166 healthy individuals (52.5%) served as controls. Results: In the TNF-α rs1800750, the GA genotype was significantly more common in cases with pneumonia-induced sepsis and septic shock when compared to the control group. The AA genotype was significantly more common in pneumonia-induced septic shock cases than in controls. TNF-α rs361525 demonstrated no significant changes across the groups. The CG and GG genotypes in the IL-6 rs1800795 were significantly higher in pneumonia-induced sepsis and septic shock cases compared to controls. The CG genotype of the IL-6 rs1800796 revealed a significantly lower proportion in the pneumonia-induced septic shock group as compared to controls. Conclusion: We found that TNF-α rs1800750, IL-6 rs1800795, and rs1800796 have a potential impact on pneumonia-induced sepsis and septic shock. © 2020 The author (s).

Keywords

interleukin-6; Pneumonia; Sepsis; TNF-α

Citation Information

Scopus Citations: 0

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