Parasitological, Histopathological and Regulatory Micro RNA Assessment in Chronic Murine Toxoplasmosis Treated with Bee Venom; [التقييم الطفيلي والنسيجي والتنظيمي للحمض النووي الريبوزي الميكروي في داء المقوسات المزمن لدى الفئران المعالج بسم النحل]

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Moubarak M.A.; Zalat R.S.; El-Sherbini M.S.; Hassan M.; Eassa A.H.A.; Ismail M.A.M.

Journal: Egyptian Journal of Veterinary Science

Publisher: National Information and Documentation Centre

Publication Date: 17 March 2025

Volume / Issue: Volume 57 / Issue 5

Pages: 343–354

ISSN: 11100222

DOI: 10.21608/ejvs.2025.343507.2552

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Moubarak M.A., Parasitology Department, Theodor Bilharz Research Institute, Cairo, Egypt; Zalat R.S., Parasitology Department, Theodor Bilharz Research Institute, Cairo, Egypt; El-Sherbini M.S., Medical Parasitology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; Hassan M., Immunology Department, Theodor Bilharz Research Institute, Cairo, Egypt; Eassa A.H.A., Medical Parasitology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; Ismail M.A.M., Medical Parasitology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Abstract

THIS research aimed to compare the potential anti-toxoplasma impact of Bee venom (B.v.) against the commercial drug spiramycin (SPI) on chronic toxoplasmosis parasitologically. A histopathological evaluation of the me49 infection was performed on the brain, liver, and lungs. Host regulatory microRNAs miR-712-3p and miR-146b-5p were measured before and after the tested drugs were administered in the sera of Swiss albino mice. Group A served as the control group, subdivided into 4 subgroups, while Group B was further separated into four me49 infected subgroups. When compared to the positive control, the combination of B.v. and SPI had the best outcomes, with a statistically significant 94.1% reduction in brain cyst count. Me49 infection resulted in a significant rise in the level of miR-712-3p expression in rats’ serum. Furthermore, after infection, there was a 50-fold rise in miR-146b-5p in host sera. Following the tested medications' treatment of the diseased mice, these levels dropped. © 2026 National Information and Documentation Center (NIDOC)

Keywords

Bee venom; Histopathology; Me49 strain; Mice; miR-146b-5p; miR-712-3p; Spiramycin; Toxoplasma

Citation Information

Scopus Citations: 0

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