Potential Role of the Tie2/ Angiopoietin System in Hepatitis C Virus- Induced Hepatocellular Carcinoma

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Fouad R.; Madkour B.; Zahran M.; Rahim A.A.; Salem D.; Nassar O.; Elnashar S.; Mahmoud O.

Journal: Asian Pacific Journal of Cancer Prevention

Publisher: Asian Pacific Organization for Cancer Prevention

Publication Date: 1 December 2024

Volume / Issue: Volume 25 / Issue 12

Pages: 4137–4144

ISSN: 15137368

DOI: 10.31557/APJCP.2024.25.12.4137

Scopus: View on Scopus

PubMed: 39733402

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Fouad R., Department of Hematology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Madkour B., Department of Hematology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Zahran M., Department of Hematology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Rahim A.A., Department of Hepato-Gastroenterology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Salem D., Department of Bacteriology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Nassar O., Department of Obstetrics and Gynecology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt; Elnashar S., Department of Anesthesiology and Intensive Care5, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt; Mahmoud O., Department of Hematology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt

Abstract

Background: The Tie2/Ang pathway was found to be involved in forming tumor blood vessels in various tumors. The goal of this study was to evaluate the value of Tie2/Ang pathway as a novel biomarkers for the early detection of chronic hepatitis C virus (CHC)-related hepatocellular carcinoma (HCC). And the possibility of their future application in HCC treatment. Methods: Flow cytometry was performed to identify and count Tie2 expressing monocytes (TEMs) in peripheral blood monocytes from HCC patients (n = 25), CHC cirrhotic patients (n = 25) and healthy volunteers (n = 25). In addition, Angiopoietin 1 and 2 (Ang) levels in the serum were determined by enzyme linked immunosorbent assay (ELIZA). Results: Percentage of TEMs in peripheral blood monocytes, serum Ang2 levels and Ang2/Ang1 ratio significantly increased in HCC patients compared with CHC patients and healthy controls (P< 0.001). However significant increase was only noticed in serum Ang1 levels in HCC group compared to the control group (P <0.05). Conclusions: TEMs may promote angiogenesis in HCC regarding the Ang2/Tie2 signal pathway. Percentage of TEMs in peripheral blood monocytes, Ang2 serum levels and Ang2/Ang1 ratio may be applied as a biomarkers for identifying CHC-related HCC. Moreover, inhibiting the proangiogenic functions of this pathway may represent a promising strategy to improve the efficacy of current treatments for HCC. © (2024), (Asian Pacific Organization for Cancer Prevention). All rights reserved.

Keywords

HCC; TEMs; Tie2/Ang pathway; Adult; Angiopoietin-1; Angiopoietin-2; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Control Studies; Female; Follow-Up Studies; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Monocytes; Neovascularization, Pathologic; Prognosis; Receptor, TIE-2; angiopoietin 1; angiopoietin 2; angiopoietin receptor; ANGPT1 protein, human; ANGPT2 protein, human; TEK protein, human; tumor marker; blood; case control study; chronic hepatitis C; complication; follow up; human; liver cell carcinoma; liver tumor; metabolism; monocyte; neovascularization (pathology); pathology; virology

Citation Information

Scopus Citations: 0

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