GC-MS analysis, anti-inflammatory and anti-proliferative properties of the aerial parts of three Mesembryanthemum spp.

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Mohamed H.R.; Hamed M.M.; El-Wakil E.A.; Okasha H.

Journal: Toxicology Reports

Publisher: Elsevier Inc.

Publication Date: December 2024

Volume / Issue: Volume 13

Article No.: 101829

ISSN: 22147500

DOI: 10.1016/j.toxrep.2024.101829

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Mohamed H.R., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornish El-Nile, Warrak El-Hadar, Giza, 12411, Egypt; Hamed M.M., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornish El-Nile, Warrak El-Hadar, Giza, 12411, Egypt; El-Wakil E.A., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornish El-Nile, Warrak El-Hadar, Giza, 12411, Egypt; Okasha H., Department of Biochemistry and Molecular Biology, Theodor Bilharz Research Institute, Kornish El-Nile, Warrak El-Hadar, Giza, 12411, Egypt

Abstract

Background: Due to their variability and safety, widespread research on phytochemicals continually encourages researchers to study various plants for their potential health benefits. Objectives: This study aims to explore the phytochemical constituents of the aerial parts of three Mesembryanthemum spp.; M. nodiflorum, M. forsskaolii, and M. cordifolium existed in Egyptian nature using GC-MS analysis and studying their different biological activities in correlation to computational analysis. Methods: Investigation of in vitro anti-inflammatory and anticancer activities and in silico studies of identified major compounds on VEGFR. Results: Thirty-three compounds were identified, octadecanoic acid, 2, 3-dihydroxypropyl ester, and 1H-Indene, 1-hexadecyl-2, 3-dihydro are the common compounds in the three extracts with different percentages. M. forsskaolii is the most extract with diverse phytoconstituents showing significant anticancer properties against the CACO2 cells with IC50 value equal to 31.78 µg/mL. Nevertheless, all extracts showed potent anti-inflammatory activity at high concentrations (500 µg/mL). M. nodiflorum, M. forsskaolii, and M. cordifolium had IC50 on HepG2 cells equal to 73.64, 88.18, and 87.82 µg/mL. Molecular findings showed the three extracts had distinct effects on apoptosis modulation in HepG2 cells. Conclusion The findings suggest that the studied extracts had potential therapeutic properties as anti-inflammatory and anticancer agents, supported by an in-silico interaction study. © 2024 The Authors

Keywords

anti-inflammatory; Colon cancer; GC-MS; HCC; Mesembryanthemum spp.; RBCs toxicity; alpha fetoprotein; chemical compound; glycerol stearate; indene; lactate dehydrogenase; ligand; phytochemical; plant extract; protein Bax; protein bcl 2; protein Bid; protein p53; PUMA protein; stearic acid; vasculotropin; aerial plant part; antiinflammatory activity; antineoplastic activity; antiproliferative activity; apoptosis; Article; bioinformatics; biological activity; Caco-2 cell line; chemical structure; cheminformatics; computer model; computer prediction; cytotoxicity; DPPH radical scavenging assay; enzyme assay; enzyme linked immunosorbent assay; erythrocyte; extraction; gene expression; hemolysis assay; Hep-G2 cell line; human; human cell; IC50; in silico design; in vitro study; liver cell carcinoma; mass fragmentography; Mesembryanthemum; Mesembryanthemum cordifolium; Mesembryanthemum forsskaolii; Mesembryanthemum nodiflorum; microscopy; molecular weight; plant; plant taxonomy; protein denaturation; RNA extraction; RNA isolation; sandwich ELISA; stereochemistry; structure analysis; upregulation

Citation Information

Scopus Citations: 2

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