Advances in understanding cisplatin-induced toxicity: Molecular mechanisms and protective strategies

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Elmorsy E.A.; Saber S.; Hamad R.S.; Abdel-Reheim M.A.; El-kott A.F.; AlShehri M.A.; Morsy K.; Salama S.A.; Youssef M.E.

Journal: European Journal of Pharmaceutical Sciences

Publisher: Elsevier B.V.

Publication Date: December 2024

Volume / Issue: Volume 203

Article No.: 106939

ISSN: 9280987

DOI: 10.1016/j.ejps.2024.106939

Scopus: View on Scopus

PubMed: 39423903

Document Type: Review

Access: All Open Access; Gold Open Access

Authors and Affiliations

Elmorsy E.A., Department of Pharmacology and Therapeutics, College of Medicine, Qassim University, Buraidah, 51452, Saudi Arabia; Saber S., Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt; Hamad R.S., Biological Sciences Department, College of Science, King Faisal University, Al Ahsa, 31982, Saudi Arabia, Central Laboratory, Theodor Bilharz Research Institute, Giza, 12411, Egypt; Abdel-Reheim M.A., Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 62521, Egypt; El-kott A.F., Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia, Department of Zoology, Faculty of Science, Damanhour University, Egypt; AlShehri M.A., Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia; Morsy K., Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia, Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt; Salama S.A., Department of Zoology, Faculty of Science, Damanhour University, Egypt, Department of Biology, College of Science, Jazan University, Jazan, 45142, Saudi Arabia; Youssef M.E., Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt

Abstract

Cisplatin, a widely used chemotherapeutic agent, has proven efficacy against various malignancies. However, its clinical utility is hampered by its dose-limiting toxicities, including nephrotoxicity, ototoxicity, neurotoxicity, and myelosuppression. This review aims to provide a comprehensive overview of cisplatin toxicity, encompassing its underlying mechanisms, risk factors, and emerging therapeutic strategies. The mechanisms of cisplatin toxicity are multifactorial and involve oxidative stress, inflammation, DNA damage, and cellular apoptosis. Various risk factors contribute to the interindividual variability in susceptibility to cisplatin toxicity. The risk of developing cisplatin-induced toxicity could be related to pre-existing conditions, including kidney disease, hearing impairment, neuropathy, impaired liver function, and other comorbidities. Additionally, this review highlights the emerging therapeutic strategies that could be applied to minimize cisplatin-induced toxicities and aid in optimizing cisplatin treatment regimens, improving patient outcomes, and enhancing the overall quality of cancer care. © 2024 The Author(s)

Keywords

Apoptosis; Cisplatin; DNA Adducts; Ferroptosis; Multiple organ toxicity; Necroptosis; Animals; Antineoplastic Agents; DNA Damage; Humans; Neoplasms; Oxidative Stress; antineoplastic agent; adverse drug reaction; bone marrow suppression; DNA adduct; drug interaction; drug therapy; drug toxicity; hearing impairment; human; inflammation; kidney disease; liver disease; nephrotoxicity; neurotoxicity; ototoxicity; pharmacology; preexisting condition; review; risk factor; side effect; therapy; animal; drug effect; neoplasm

Citation Information

Scopus Citations: 181

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