Evaluation of the prophylactic and therapeutic effects of selenium and vitamin E on the muscular phase of experimental Trichinella spiralis infection in mice

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Mohamed A.M.; Hegab A.M.; Amer S.I.I.; Zalat R.S.; Shoeib E.Y.; Abdel-Shafi I.R.

Journal: Journal of Parasitic Diseases

Publisher: Springer

Publication Date: 22 November 2024

Volume / Issue: Volume 49 / Issue 2

Pages: 378–388

Article No.: e140

ISSN: 9717196

DOI: 10.1007/s12639-024-01762-3

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Green Open Access

Authors and Affiliations

Mohamed A.M., Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt; Hegab A.M., Department of Developmental Pharmacology, Egyptian Drug Authorization (EDA), Giza, Egypt; Amer S.I.I., Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt; Zalat R.S., Department of Parasitology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Shoeib E.Y., Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt; Abdel-Shafi I.R., Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt

Abstract

Trichinellosis is a foodborne parasitic infection, where the Trichinella spiralis larvae invade, grow and dwell in muscle cells, transforming them into nurse cells for nutrient supply and protective shelter. The present study evaluated the prophylactic and therapeutic impact of the antioxidants selenium (Se) and vitamin E (Vit E), alone and in combinations with albendazole (ALB), on muscular phase of experimental Trichinella spiralis infection in mice. Forty-eight Swiss albino mice were divided into 3 main groups: control, prophylactic, and therapeutic groups, with further subgrouping according to the received treatment. Larval count, inflammation around the encapsulated larvae, and oxidative stress markers were assessed. All groups receiving treatment showed a significant reduction in larvae count/gm muscle compared to the infected control group. In the prophylactic group, combined VitE-Se achieved the highest reduction, 58.4% and 51% in the diaphragm and intercostals, respectively. Whereas in the therapeutic group combined VitE-Se-ALB showed the maximum reduction rates of 90.4% and 84.4% in the diaphragm and intercostals, respectively. Varying grades of cellular inflammatory infiltration were detected around the capsule in various groups, with marked reduction in degree of inflammation in all combination groups containing ALB. Oxidative stress markers malondialdehyde (MDA) and superoxide dismutase (SOD) levels showed a significant decrease in treated muscle tissues, the lowermost level was detected in the VitE-Se-ALB combination group. In conclusion, combined Vit E-Se reduced muscle larval burden in the prophylactic group, potentiated the antiparasitic action of ALB in the therapeutic group, and demonstrated anti-inflammatory and antioxidant effects. © Indian Society for Parasitology 2024.

Keywords

MDA; Myositis; Selenium; SOD; Trichinella spiralis; Vitamin E; albendazole; alpha tocopherol; antioxidant; malonaldehyde; superoxide dismutase; thiobarbituric acid reactive substance; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; cell infiltration; controlled study; diaphragm; histology; histopathology; inflammation; larva; lipid peroxidation; male; monotherapy; mouse; muscle tissue; nonhuman; nutrient supply; oxidative stress; parasitosis; physiological stress; scoring system; trichinosis

Citation Information

Scopus Citations: 0

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