Phytochemical Profiling, Cytotoxicity and Anti-inflammatory Potential of Salvia hispanica L. Seeds

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Mohamed H.R.; El-Wakil E.A.; Hamed M.M.; El-Shahid Z.A.E.-K.

Journal: Egyptian Journal of Chemistry

Publisher: National Information and Documentation Centre

Publication Date: 14 October 2024

Volume / Issue: Volume 67 / Issue 12

Pages: 409–422

ISSN: 4492285

DOI: 10.21608/ejchem.2024.303803.10000

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Mohamed H.R., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Korniash El-Nile, Warrak El-Hadar, Giza, 12411, Egypt; El-Wakil E.A., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Korniash El-Nile, Warrak El-Hadar, Giza, 12411, Egypt; Hamed M.M., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Korniash El-Nile, Warrak El-Hadar, Giza, 12411, Egypt; El-Shahid Z.A.E.-K., Department of Chemistry of Natural and Microbial Products, National Research Centre, Dokki, Giza, 12622, Egypt

Abstract

Seeds of Salvia hispanica L. (chia seeds) have recently gained increasing attention as a functional food with numerous therapeutic benefits. The ethyl acetate and the methanol extracts of chia seeds were evaluated for their anti-inflammatory potential by measuring Nitric oxide production in LPS-stimulated RAW 264.7 cells and cytotoxic activity against HepG2, Paca II, HCT116, and HT29 cancer cell lines using MTT assay. The phytochemical composition was analyzed via GC-MS and UPLC-MS. Nineteen compounds were tentatively identified in the methanol extract via LC-MS and 10 compounds from the ethyl acetate extract by GC/MS. The ethyl acetate extract showed a remarkable cytotoxic effect against HepG2 and Paca-II with IC50 of 11 µg/mL and 87.7 µg/mL, respectively. The pre-treatment with both extracts significantly suppressed the NO production in LPS-stimulated RAW 264.7 cells. The results indicated that; S. hispanica L. seeds could be used as a potent anti-inflammatory and anticancer herbal medicine especially against hepatocellular carcinoma. ©2024 National Information and Documentation Center (NIDOC)

Keywords

anti-inflammatory; anticancer; GC/MS; Salvia hispanica L; UPLC-ESI-MS

Citation Information

Scopus Citations: 3

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