Chemical composition and biological activities of nine essential oils obtained from Algerian plants

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Guendouz C.; Guenane H.; Bakchiche B.; Ascrizzi R.; Flamini G.; Bardaweel S.K.; Sayed A.M.; Ghareeb M.A.

Journal: Natural Product Research

Publisher: Taylor and Francis Ltd.

Publication Date: 9 October 2024

Volume / Issue: Volume 40 / Issue 4

Pages: 1003–1012

ISSN: 14786419

DOI: 10.1080/14786419.2024.2412308

Scopus: View on Scopus

PubMed: 39381930

Document Type: Article

Access: All Open Access; Green Open Access

Authors and Affiliations

Guendouz C., Laboratory of Biological and Agricultural Sciences (LBAS), Amar Telidji University, Laghouat, Algeria; Guenane H., Laboratory of Biological and Agricultural Sciences (LBAS), Amar Telidji University, Laghouat, Algeria; Bakchiche B., Laboratory of Biological and Agricultural Sciences (LBAS), Amar Telidji University, Laghouat, Algeria; Ascrizzi R., Dipartimento di Farmacia, Università di Pisa, Pisa, Italy; Flamini G., Dipartimento di Farmacia, Università di Pisa, Pisa, Italy; Bardaweel S.K., Department of Pharmaceutical Sciences, School of Pharmacy, University of Jordan, Amman, Jordan; Sayed A.M., Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt; Ghareeb M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute Kornaish El Nile, Giza, Egypt

Abstract

The essential oils (EOs) from nine species (Artemisia campestris, A. herba-alba, Juniperus foetidissima, Laurus nobilis, Mentha pulegium, M. spicata, Rosmarinus officinalis, Salvia officinalis, and Thymus vulgaris) of the Algerian flora have been hydrodistilled, analysed, and tested for their antioxidant and antiproliferative properties. A. campestris EO showed a higher content of terpene hydrocarbons; A. herba-alba EO was mainly rich in their oxygenated derivatives. Sesquiterpenes were the most abundant compounds in J. foetidissima EO, while oxygenated monoterpenes and phenylpropanoids prevailed in L. nobilis EO. The other EOs were rich in oxygenated monoterpenes, with quality–quantitative differences. T. vulgaris and L. nobilis performed better in all the antioxidant assays, respectively with IC50 values ranging from 0.0002 and 0.0012 mg/mL in the CUPRAC assay to 2.83 and 3.50 mg/mL in the FRAP assay. T. vulgaris was also the only EO exhibiting an antiproliferative activity towards the human breast (MCF-7) and lung (A549) cancer cell lines. © 2024 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Antioxidant activity; antiproliferative activity; GC–MS; Laurus nobilis; Thymus vulgaris; Algeria; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Cell Proliferation; Humans; Juniperus; Laurus; Mentha pulegium; Mentha spicata; Monoterpenes; Oils, Volatile; Plant Oils; Rosmarinus; Salvia officinalis; Sesquiterpenes; Terpenes; Thymus Plant; acyclic monoterpenoid; antioxidant; camphor; essential oil; flavonoid; phenol derivative; phenylpropanoid; pinene; plant extract; sesquiterpene; terpene; unclassified drug; antineoplastic agent; monoterpene; vegetable oil; A-549 cell line; Algerian; antibacterial activity; antiinflammatory activity; antimicrobial activity; antineoplastic activity; Article; bacterial growth; biological activity; chemical composition; controlled study; cytotoxicity; disk diffusion; DPPH radical scavenging assay; gas chromatography; geographical variation (species); IC50; in vitro study; mass fragmentography; mass spectrometry; minimum inhibitory concentration; MTT assay; nonhuman; phytochemistry; Pseudomonas aeruginosa; Staphylococcus aureus; traditional medicine; chemistry; drug effect; human; Thymus (plant); tumor cell line

Citation Information

Scopus Citations: 5

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