Mesenchymal Stem Cells in Liver Diseases: Present Status and Future Perspectives

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Atta S.; Megahed F.; Atta A.H.

Journal: Experimental and Clinical Transplantation

Publisher: Baskent University

Publication Date: August 2024

Volume / Issue: Volume 22 / Issue 8

Pages: 586–599

ISSN: 13040855

DOI: 10.6002/ect.2023.0357

Scopus: View on Scopus

PubMed: 39254070

Document Type: Review

Authors and Affiliations

Atta S., Department of Immunology, Theodor Bilharz Research Institute, Cairo, Egypt; Megahed F., Department of Nucleic Acid Research Department, Genetic Engineering and Biotechnological Research Institute (GEBRI), City for Scientific Researches and Technological Applications (SRTA-City), Alexandria, 21934, Egypt; Atta A.H., Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt

Abstract

Liver disease is a major worldwide health and economic problem. Allograft liver transplant is the only effective therapy for end-stage liver disease. The shortage of donors, the high costs, postoperative complications, and lifelong immunosuppression are rate-limiting factors for this established line of treatment. Hence, searching for therapeutic alter-natives is mandatory. Stem cells are attractive candi-dates for cell-based therapy for their potential to support liver regeneration with few complications. They can differentiate into specialized cells, including hepatocytes to restore liver structure and function. Stem cells originating from different sources have been investigated for the treatment of liver diseases. In this review, we highlight the role of stem cells as an appropriate source for liver cell replacement in different liver diseases. © Başkent University 2024.

Keywords

Cirrhosis; End-stage liver disease; Liver regeneration; Animals; Cell Differentiation; Hepatocytes; Humans; Liver; Liver Diseases; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Phenotype; Recovery of Function; Regenerative Medicine; Treatment Outcome; allograft; cell therapy; end stage liver disease; fibrosis; human; immune deficiency; immunosuppressive treatment; line of treatment; liver cell; liver disease; liver structure; liver transplantation; mesenchymal stem cell; nonhuman; pharmacokinetics; postoperative complication; review; therapy; animal; convalescence; pathology; surgery; transplantation

Citation Information

Scopus Citations: 1

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