Evaluation of adropin, fibroblast growth factor-1 (FGF-1), and Toll-like receptor-1 (TLR1) biomarkers in patients with inflammatory bowel disease: gene expression of TNF-α as a marker of disease severity

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Zaki M.; Orban H.A.; Mahmoud M.; Youness E.R.; Booles H.F.; Khalil W.K.B.; Wafy W.; El-Atrebi K.A.; Hamed K.; El-Bassyouni H.T.

Journal: Egyptian Journal of Medical Human Genetics

Publisher: Springer Nature

Publication Date: 5 June 2024

Volume / Issue: Volume 25 / Issue 1

Article No.: 63

ISSN: 11108630

DOI: 10.1186/s43042-024-00533-2

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Zaki M., Biological Anthropology Department, Medical Researches and Clinical Studies Institute– National Research Centre Cairo, Cairo, Egypt; Orban H.A., Medical Biochemistry Department, Medical Researches and Clinical Studies Institute– National Research Centre Cairo, Cairo, Egypt; Mahmoud M., Medical Biochemistry Department, Medical Researches and Clinical Studies Institute– National Research Centre Cairo, Cairo, Egypt; Youness E.R., Medical Biochemistry Department, Medical Researches and Clinical Studies Institute– National Research Centre Cairo, Cairo, Egypt; Booles H.F., Department of Cell Biology, National Research Centre, Cairo, Egypt; Khalil W.K.B., Department of Cell Biology, National Research Centre, Cairo, Egypt; Wafy W., Public Health, Theodor Bilharz Research Institute, Imbaba, Giza, 12411, Egypt; El-Atrebi K.A., General Medicine and Hepatology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; Hamed K., Clinical Genetics Department, National Research Centre, El-Tahreer Street, Dokki, Cairo, Egypt; El-Bassyouni H.T., Clinical Genetics Department, National Research Centre, El-Tahreer Street, Dokki, Cairo, Egypt

Abstract

Background: Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of unknown etiology and unpredictable course. The aim of the work was to assess the levels of adropin, fibroblast growth factor-1 (FGF-1), and Toll-like receptor-1 (TLR1) biomarkers in IBD patients compared to controls and evaluate the gene expression of TNF-α as a marker of disease severity. Methods: Adropin, fasting serum FGF-1 levels, TLR1, and TNF-α were measured in 60 IBD patients. They were also compared with 58 healthy controls matching age and gender. Moreover, the blood cells cDNA copy number of TNF-α were determined as a marker of severity. Results: Adropin and TLR1 levels were significantly lower in patients than controls. FGF-1 was reduced but not statistically significant. The expression of TNF-α gene in the IBD patients was significantly increased (42%) in comparison with control samples (P < 0.001). Conclusions: Adropin, IGF-I, and Toll-like receptor-1 biomarkers may have a role in the intricate pathophysiology of IBD and may possibly operate as predictors of disease activity. Thus, they may be therapeutic targets for IBD. Moreover, the expression of TNF-α gene can be used as a marker of severity. © The Author(s) 2024.

Keywords

Adropin; cDNA; FGF-1; Inflammatory bowel disease; TLR1; biological marker; complementary DNA; fibroblast growth factor 1; peptide hormone; RNA directed DNA polymerase; toll like receptor 1; tumor necrosis factor; unclassified drug; abdominal pain; adult; arthritis; Article; bleeding; blood level; blood sampling; body weight loss; consanguinity; controlled study; denaturation; depression; diarrhea; digestive system function disorder; disease severity; enzyme linked immunosorbent assay; evaluation study; fasting; female; gene expression; human; major clinical study; male; pedigree analysis; real time polymerase chain reaction; reverse transcription; spectrophotometry; vomiting

Citation Information

Scopus Citations: 3

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