Phyto-synthesized silver nanoparticles from Sargassum subrepandum: anticancer, antimicrobial, and molluscicidal activities

Theodor Bilharz Research Institute

Bibliographic Information

Authors: El-Sayed H.; Abdelsalam A.; Morad M.Y.; Sonbol H.; Ibrahim A.M.; Tawfik E.

Journal: Frontiers in Plant Science

Publisher: Frontiers Media SA

Publication Date: 8 May 2024

Volume / Issue: Volume 15

Article No.: 1403753

ISSN: 1664462X

DOI: 10.3389/fpls.2024.1403753

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

El-Sayed H., Botany and Microbiology Department, Faculty of Science, Helwan University, Helwan, Egypt; Abdelsalam A., Botany and Microbiology Department, Faculty of Science, Helwan University, Helwan, Egypt; Morad M.Y., Zoology and Entomology Department, Faculty of Science, Helwan University, Helwan, Egypt; Sonbol H., Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; Ibrahim A.M., Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt; Tawfik E., Botany and Microbiology Department, Faculty of Science, Helwan University, Helwan, Egypt

Abstract

In the realm of nanotechnology, the use of algae to produce nanoparticles is an environmentally friendly, sustainable, and economically viable strategy. In the present study, the brown macroalgae Sargassum subrepandum was utilized to effectively produce silver nanoparticles (AgNPs). Through various characterization techniques, the AgNPs’ structural integrity was confirmed. AgNPs exhibited significant antimicrobial activity against Pseudomonas aeruginosa and Fusarium equiseti. AgNPs showed cytotoxic effects on the MCF-7 breast adenocarcinoma cell line with an IC50 of 12.5 µg/ml. Treatment with AgNPs resulted in a marked reduction in cell viability, alongside evident apoptotic and necrotic morphological changes in the cancer cells. Through molecular docking studies, a deeper understanding of the interaction between AgNPs and crucial proteins related to cancer has been achieved, AgNPs showed a promising molluscicidal action on Biomphalaria alexandrina snails, a Schistosoma mansoni intermediate host. The half-lethal dose (LC50) of AgNPs was determined to be 0.84 mg/L. The potential consequences of its administration include potential disruptions to the glycolysis profile, as well as potential impacts on the steroidal hormone’s estrogen and testosterone and certain kidney function tests. This study highlights the diverse uses of algae-synthesized AgNPs, ranging from healthcare to environmental management, demonstrating their importance in advancing nano-biotechnological solutions. Copyright © 2024 El-Sayed, Abdelsalam, Morad, Sonbol, Ibrahim and Tawfik.

Keywords

Anticancer; antimicrobial; Biomphlaria alexandrina; breast cancer; in silico; macroalagae; Sargassum subrepandum

Citation Information

Scopus Citations: 16

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