Oral microbiome dysbiosis and gastrointestinal diseases: a narrative review

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Elghannam M.T.; Hassanien M.H.; Ameen Y.A.; Turky E.A.; ELattar G.M.; ELRay A.A.; ELTalkawy M.D.

Journal: Egyptian Liver Journal

Publisher: Springer Science and Business Media Deutschland GmbH

Publication Date: 6 May 2024

Volume / Issue: Volume 14 / Issue 1

Article No.: 32

ISSN: 20906218

DOI: 10.1186/s43066-024-00340-9

Scopus: View on Scopus

Document Type: Review

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Elghannam M.T., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; Hassanien M.H., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; Ameen Y.A., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; Turky E.A., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; ELattar G.M., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; ELRay A.A., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt; ELTalkawy M.D., Hepatogastroenterology Department, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Mouth is the gateway to the total body wellness. Accordingly, oral microbiome influences overall health of an individual. Oral microbiome plays a key role in shaping up the host’s health profile. Obvious differences have been reported between patients with gastrointestinal diseases and healthy controls. The oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Oral bacteria can disseminate to the distal gut via enteral or hematogenous routes. The translocation of oral microbes to the gut may give rise to a variety of gastrointestinal diseases including Helicobacter-induced diseases, irritable bowel syndrome, inflammatory bowel disease, celiac disease, and colorectal cancer. Understanding the role of the oral-to-gut microbial translocation in the pathogenesis will contribute to precise diagnosis and effective treatment. In this review, we aim to highlight the role of oral microbiota dysfunction in various gastrointestinal disorders. © The Author(s) 2024.

Keywords

CRC; Helicobacter-induced diseases; IBD; IBS; Oral microbiota

Citation Information

Scopus Citations: 20

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