Biological, biochemical and genotoxicological alterations of Benzylamine on Biomphalaria alexandrina snails and its Schistosoma mansoni larvicidal potential

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Ibrahim A.M.; Youssef A.A.; Youssef A.B.A.; Nasr S.M.

Journal: Pesticide Biochemistry and Physiology

Publisher: Academic Press Inc.

Publication Date: May 2024

Volume / Issue: Volume 201

Article No.: 105855

ISSN: 483575

DOI: 10.1016/j.pestbp.2024.105855

Scopus: View on Scopus

PubMed: 38685235

Document Type: Article

Authors and Affiliations

Ibrahim A.M., Medical Malacology Department, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt; Youssef A.A., Medical Malacology Department, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt; Youssef A.B.A., Agricultural Genetics Engineering Research Institute, Agricultural Research Center, Giza, Egypt; Nasr S.M., Biochemistry, Molecular Biology and Medicinal chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt, School of Biotechnology, Badr University in Cairo, Cairo, Badr City, 11829, Egypt

Abstract

Biomphalaria spp. snails are freshwater gastropods that responsible for Schistosoma mansoni transmission. Schistosomiasis is a chronic illness that occurred in underdeveloped regions with poor sanitation. The aim of the present study is to evaluate the molluscicidal activity of benzylamine against B. alexandrina snails and it larvicidal effects on the free larval stages of S. mansoni. Results showed that benzylamine has molluscicidal activity against adult B. alexandrina snails after 24 h of exposure with median lethal concentration (LC50) 85.7 mg/L. The present results indicated the exposure of B. alexandrina snails to LC10 or LC25 of benzylamine resulted in significant decreases in the survival, fecundity (eggs/snail/week) and reproductive rates, acetylcholinesterase, albumin, protein, uric acid and creatinine concentrations, levels of Testosterone (T) and 17β Estradiol (E), while alkaline phosphatase levels were significantly increased in comparison with control ones. The present results showed that the sub lethal concentration LC50 (85.7 mg/L) of benzylamine has miracidial and cercaricidal activities, where the Lethal Time (LT50) for miracidiae was 17.08 min while for cercariae was 30.6 min. Also, results showed that were decreased significantly after exposure to sub lethal concentrations compared with control. The present results showed that the expression level of NADH dehydrogenase subunit 1 (ND1) genes and cytochrome oxidase subunit I (COI) in B. alexandrina snails exposed to LC10 or LC25 concentrations benzylamine were significantly decreased compared to the control groups. Therefore, benzylamine could be used as effective molluscicide to control schistosomiasis. © 2024 Elsevier Inc.

Keywords

Benzylamine; Biomphalaria alexandrina; Genotoxicit; Physiological alterations; S. mansoni; Animals; Biomphalaria; Larva; Molluscacides; Schistosoma mansoni; molluscacide; animal; drug effect

Citation Information

Scopus Citations: 4

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