CHEMICAL PROFILE AND MEMBRANE STABILIZATION ACTIVITY: UNVEILING THE ANTI-INFLAMMATORY MECHANISM OF MYRRH

Theodor Bilharz Research Institute

Bibliographic Information

Authors: El-Wakil E.A.; Abdel-Hady H.; Morsi E.A.

Journal: Bulletin of Pharmaceutical Sciences. Assiut

Publisher: Assiut University

Publication Date: 21 April 2024

Volume / Issue: Volume 47 / Issue 1

Pages: 233–248

ISSN: 11100052

DOI: 10.21608/BFSA.2024.271298.2038

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

El-Wakil E.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile St., Warrak El-Hadder, Imbaba, Mail Box 30, P.O. 12411, Giza, Egypt; Abdel-Hady H., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile St., Warrak El-Hadder, Imbaba, Mail Box 30, P.O. 12411, Giza, Egypt; Morsi E.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile St., Warrak El-Hadder, Imbaba, Mail Box 30, P.O. 12411, Giza, Egypt

Abstract

Commiphora myrrha has been extensively used in traditional medicine. The biochemical characters of Commiphora myrrha hydro-methanolic and petroleum ether extracts were studied. The phenolic and flavonoid contents, DPPH assay, in vitro anti-inflammation activity of them by determining the membrane stabilizing activity and NO assay as well as chemical profile by GC-MS and HPLC were investigated. The results showed that phenolic and flavonoid content of hydro-methanolic extract (158.26 ± 3.44 mg Gallic acid equivalent (GAE)/g of extract and 91.43 ± 3.33 Rutin/g extract, respectively was higher than those of petroleum ether (126.16 ± 0.42 mg GAE/g of extract and 61.97 ± 2.5 mg Rutin/g extract, respectively). Also, hydro-methanolic has potent antioxidant activity than petroleum ether (IC50 = 46.56 ± 1.06 and 66.13 ± 1.64 μg/mL, respectively). Moreover, hydro-methanolic extract exhibited strong stabilizing effects on human red blood cell membrane as well as strong NO production inhibition. HPLC for hydro-methanolic extract showed 13 phenolic compounds and 8 flavonoid one. While, GC-MS analysis exhibited 49 compounds in the petroleum ether extract and 45 ones in the hydro-hydro-methanolicic extract. In general, the anti-inflammatory effect is correlated to antioxidant activity of the plant depends on the phenolic and flavonoid content. © 2024 Assiut University. All rights reserved.

Keywords

DPPH; GC-MS; HPLC; Hydro-methanolic; Nitric oxide; Petroleum ether; acid; ascorbic acid; aurantiin; benzoic acid; caffeic acid; catechin; catechol; chlorogenic acid; cinnamic acid; ellagic acid; ferulic acid; flavone; flavonoid; gallic acid; hesperidin; indometacin; kaempferol; luteolin; para coumaric acid; phenol derivative; phytochemical; protocatechuic acid; protocatechulic acid; pyrogallol; quercetin; rutoside; salicylic acid; syringenic acid; unclassified drug; antiinflammatory activity; antioxidant activity; Article; biochemical analysis; chemical analysis; chemical fingerprinting; Commiphora myrrha; controlled study; DPPH radical scavenging assay; erythrocyte membrane; hemolysis; high performance liquid chromatography; human; human cell; in vitro study; mass fragmentography; membrane stabilization; RAW 264.7 cell line

Citation Information

Scopus Citations: 2

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