Risk of atrial fibrillation development in adolescent patients with inflammatory bowel disease

Theodor Bilharz Research Institute

Bibliographic Information

Authors: El Amrousy D.; El Ashry H.; Maher S.; Hamza M.; Hasan S.

Journal: European Journal of Pediatrics

Publisher: Springer Science and Business Media Deutschland GmbH

Publication Date: 12 February 2024

Volume / Issue: Volume 183 / Issue 4

Pages: 1917–1923

ISSN: 3406199

DOI: 10.1007/s00431-024-05468-9

Scopus: View on Scopus

PubMed: 38347261

Document Type: Article

Access: All Open Access; Green Open Access; Hybrid Gold Open Access

Authors and Affiliations

El Amrousy D., Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt; El Ashry H., Hepatology and Tropical Medicine Departments, Faculty of Medicine, Tanta University, Tanta, Egypt; Maher S., Theodor Bilharz Research Institute, Cairo, Egypt; Hamza M., Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt; Hasan S., Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt

Abstract

There is increasing evidence linking chronic inflammation to the initiation and continuation of atrial fibrillation (AF). Inflammatory bowel diseases (IBD), namely (Crohn’s disease (CD) and ulcerative colitis (UC), are chronic systemic inflammatory disorders with both intestinal and extra-intestinal manifestations. Atrial electromechanical delay (EMD) has been known as an early marker of AF. The objective of this study was to evaluate the atrial electromechanical properties in children and adolescents with IBD during remission. One hundred IBD patients aged 12–17 years (50 with CD and 50 with UC) in remission state and 100 healthy controls were recruited for the study. Atrial electromechanical properties were measured using transthoracic echocardiography, tissue Doppler imaging, and simultaneous surface ECG recording. Interatrial EMD, left intra-atrial, and right intra-atrial EMD were calculated. IBD patients in remission state have significantly prolonged left and right intra-atrial EMD and interatrial EMD compared to healthy controls (P = 0.03, P = 0.02, and P = 0.01 respectively). No statistical difference was observed between CD and UC in terms of inter- and intra-atrial EMDs. Conclusion: Atrial EMD is increased in pediatric patients with IBD indicating the increased risk of AF development. Measurement of atrial EMD parameters might be used to predict the risk of the development of AF in pediatric patients with IBD. (Table presented.) © The Author(s) 2024.

Keywords

Adolescents; Atrial fibrillation; Children; Inflammatory bowel disease; Adolescent; Child; Colitis, Ulcerative; Crohn Disease; Echocardiography; Heart Atria; Humans; Inflammation; Inflammatory Bowel Diseases; aminosallicylate; antiinflammatory agent; azathioprine; biological product; C reactive protein; corticosteroid; gastrointestinal agent; unclassified drug; Article; atrial electromechanical delay; cardiovascular parameters; colitis; controlled study; cross-sectional study; disease course; electrocardiogram; erythrocyte sedimentation rate; female; human; major clinical study; male; proctitis; prospective study; remission; tissue Doppler imaging; transthoracic echocardiography; ulcerative colitis; complication; diagnostic imaging; heart atrium; procedures

Citation Information

Scopus Citations: 4

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