UPLC-ESI-MS polyphenolic profiling and the antimicrobial potential of Ailanthus altissima (Mill.) Swingle leaves growing in Egypt

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Mohamed H.R.; El-Wakil E.A.; El-Hashash M.M.; Shemis M.; Abdel-Hameed E.-S.S.

Journal: Journal of Research in Pharmacy

Publisher: Marmara University

Publication Date: 2024

Volume / Issue: Volume 28 / Issue 2

Pages: 516–525

ISSN: 26306344

DOI: 10.29228/jrp.715

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Mohamed H.R., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Korniash El-Nile, 12411Warrak El-Hadar, Giza, Egypt; El-Wakil E.A., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Korniash El-Nile, 12411Warrak El-Hadar, Giza, Egypt; El-Hashash M.M., Department of Chemistry, Faculty of Science, Ain-Shams University, El-Khalifa El-Mamoun, 11566 Abasia, Cairo, Egypt; Shemis M., Department of Biochemistry and Molecular Biology, Theodor Bilharz Research Institute, Korniash El-Nile, 12411Warrak El-Hadar, Giza, Egypt; Abdel-Hameed E.-S.S., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Korniash El-Nile, 12411Warrak El-Hadar, Giza, Egypt

Abstract

The need of finding out new and potent antimicrobial agents to combat the multidrug resistance pathogens becomes critical. Ailanthus altissima is characterized by its vast and remarkable therapeutic potential as a traditional folk medicine. The current study aims to investigate the polyphenolic profiling and the antimicrobial activity of the methanol extract of A. altissima leaves and its derived fractions. The antimicrobial activity was investigated through two in-vitro assays; agar well diffusion and broth microdilution against six pathogens while the polyphenolic profiling was characterized through UPLC-ESI-MS analysis. All the test pathogens were susceptible to the test samples except Mucor circinelloides. The zone of microbial growth inhibition of the samples was found in 10-40 mm range and the minimum inhibitory values ranged between 3.9 and 1000 µg/mL. The ethyl acetate fraction exhibited significant antimicrobial potential especially against P. aeruginosa, S. aureus and C. albicans where the diameters of inhibition zones were 40, 30 and 25mm, respectively and their corresponding MIC values were 3.9, 7.8 and 15.6 µg/mL, respectively. The UPLC-ESI-MS analysis of the samples revealed the tentative identification of various phenolic compounds mainly corilagin. A. altissima offers a perfect choice to be investigated as a natural and potent antimicrobial agent. © 2024 Marmara University Press.

Keywords

Ailanthus altissima; antimicrobial; corilagin; phenolics; UPLC-ESI-MS; acetic acid ethyl ester; Ailanthus altissimus extract; antibiotic agent; butanol; methanol; plant extract; polyphenol; unclassified drug; agar diffusion; Ailanthus altissimus; antibacterial activity; antibiotic sensitivity; Article; bacterial growth; broth dilution; Candida albicans; clinical assessment; controlled study; electrospray mass spectrometry; in vitro study; ion chromatography; minimum inhibitory concentration; Mucor circinelloides; nonhuman; plant growth; plant leaf; Pseudomonas aeruginosa; Staphylococcus aureus; ultra performance liquid chromatography; zone of inhibition

Citation Information

Scopus Citations: 3

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