Octopus vulgaris ink chemical profiling and validation of its potential as antioxidant, antimicrobial, anti-cancer as well as anti-Schistosomal drug in vitro; [Perfil químico da tinta de Octopus vulgaris e validação de seu potencial como antioxidante, antimicrobiano, anticancerígeno e antiesquistossomótico in vitro]

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Hamdi S.A.H.; El-Shazly M.A.M.; Fol M.F.; Mossalem H.S.; Ghareeb M.A.; Ibrahim A.M.; Aloufi A.S.; Abd El-Ghany M.N.; Korany S.M.

Journal: Arquivo Brasileiro de Medicina Veterinaria e Zootecnia

Publisher: Universidade Federal de Minas Gerais

Publication Date: 2024

Volume / Issue: Volume 76 / Issue 5

Article No.: e13217

ISSN: 1020935

DOI: 10.1590/1678-4162-13217

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Hamdi S.A.H., Zoology Department, Faculty of Science, Cairo University, Egypt; El-Shazly M.A.M., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Egypt; Fol M.F., Zoology Department, Faculty of Science, Cairo University, Egypt; Mossalem H.S., Medical Malacology Department, Theodor Bilharz Research Institute, Egypt; Ghareeb M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Egypt; Ibrahim A.M., Medical Malacology Department, Theodor Bilharz Research Institute, Egypt; Aloufi A.S., Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia; Abd El-Ghany M.N., Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, 12613, Egypt; Korany S.M., Botany and Microbiology Department, Faculty of Science, Helwan University, Cairo, 11795, Egypt

Abstract

Among marine creatures including squids, cephalopods and Octopus, one of the most unique features is production of ink which is an extremely valuable source of pharmaceuticals. The current study investigates the ink produced from Octopus vulgaris chemically as well as its potential antioxidant, anticancer, antimicrobial, and anti-schistosomal activities in vitro. Twenty-one different compounds were identified by GC-MS analysis of Octopus vulgaris ink. Results revealed that O. vulgaris ink had antioxidant capability to cover DPPH free radical when compared to ascorbic acid. Moreover, Octopus vulgaris ink exhibited antibacterial activity against Bacillus subtilis followed by Escherichia coli and Pseudomonas aeuroginosa and exhibited a molluscicidal activity against adult Biomphalaria alexandrina snails and had a distinguished mortal effect on free larval phases of Schistosoma mansoni. Furthermore, its anticancer activity was confirmed, where IC50 value of breast cancer cell line MCF-7, human hepatocellular carcinoma (HCT) and human liver cancer cell line (HepG2) were 29.8, 38.29 and 30.38μg/mL, respectively. In conclusion, ink extracted from O. vulgaris may be considered as source of valuable compounds that can be used as molluscicidal, antioxidant, antimicrobial, anticancer and anti-schistosomal agents. © (2024), (Universidade Federal de Minas Gerais). All Rights Reserved.

Keywords

anti-schistosomal; anticancer; antimicrobial; antioxidant; Octopus vulgaris; aldehyde derivative; alkadiene; alkene derivative; amphotericin B; ampicillin; animal extract; ascorbic acid; carotene; ink; ketone derivative; naphthyridine derivative; Octopus vulgaris ink; oxepane derivative; phenanthrene derivative; porphyrin derivative; pyridine derivative; pyrrolidine derivative; triterpenoid; unclassified drug; anthelmintic activity; antimicrobial activity; antineoplastic activity; antioxidant activity; antischistosomal activity; Article; Bacillus subtilis; Biomphalaria alexandrina; chemical fingerprinting; controlled study; DPPH radical scavenging assay; Escherichia coli; Hep-G2 cell line; hepatocellular carcinoma cell line; human; human cell; IC50; in vitro study; mass fragmentography; MCF-7 cell line; molluscicidal activity; nonhuman; Pseudomonas aeruginosa; Schistosoma mansoni; validation process

Citation Information

Scopus Citations: 5

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