Effect of ozone gas on viral kinetics and liver histopathology in hepatitis C patients

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Sadek A.; Abd El Hady A.M.; Olfat H.; Abd El Hady A.A.; Wafy W.; Zaki M.; Youness E.R.

Journal: Journal of Complementary and Integrative Medicine

Publisher: Walter de Gruyter GmbH

Publication Date: 10 January 2024

Volume / Issue: Volume 21 / Issue 1

Pages: 131–138

ISSN: 15533840

DOI: 10.1515/jcim-2023-0239

Scopus: View on Scopus

PubMed: 38190482

Document Type: Article

Authors and Affiliations

Sadek A., Departments of Hepatology & Gastroenterology, Theodor Bilharz Research Institute, Giza, Egypt; Abd El Hady A.M., Departments of Pathology, Theodor Bilharz Research Institute, Giza, Egypt; Olfat H., Departments of Pathology, Theodor Bilharz Research Institute, Giza, Egypt; Abd El Hady A.A., Departments of Clinical Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Wafy W., Departments of Public Health, Theodor Bilharz Research Institute, Giza, Egypt; Zaki M., Department of Biological Anthropology, Medical Researches and Clinical Studies Institute, National Research Centre, Cairo, Egypt; Youness E.R., Department of Medical Biochemistry, Medical Researches and Clinical Studies Institute, National Research Centre, Cairo, Egypt

Abstract

Objectives: We examine how well ozone/oxygen gas therapy treats chronic hepatitis C patients with varying degrees of liver fibrosis. Also to study the effect of giving multiple anti-oxidants with the ozone/oxygen gas mixture, to see if this addition would have any additive or synergistic effect. Methods: Two hundred and twenty three patients with chronic hepatitis C. Liver biopsies were carried out at after 12 weeks of administering an ozone/oxygen gas mixture. Results: The mean stage of fibrosis decreased from 1.98 to 1.41 and the mean grade of inflammation decreased from 10.08 to 7.94, both with a p value less than 0.001. After 12 weeks of treatment, mean PCR values increased. No single significant complication was recorded in a total of >9,000 settings of ozone therapy. Conclusions: Ozone oxygen gas mixture is safe and effective in treatment of hepatic fibrosis due to chronic viral hepatitis C. © 2023 Walter de Gruyter GmbH, Berlin/Boston.

Keywords

anti-oxidants; chronic liver disease; hepatitis C; liver fibrosis; ozone/oxygen gas mixture; Hepatitis C, Chronic; Humans; Liver; Liver Cirrhosis; Oxygen; Ozone; alanine aminotransferase; alkaline phosphatase; alpha tocopherol; ascorbic acid; aspartate aminotransferase; ubidecarenone; adult; aged; Article; chronic hepatitis C; controlled study; drug effect; drug efficacy; drug potentiation; drug safety; female; follow up; Hepatitis C virus; histopathology; human; human cell; human tissue; kinetics; liver biopsy; major clinical study; male; oxygen therapy; ozone therapy; phase 2 clinical trial; polymerase chain reaction; protein blood level; randomized controlled trial; single blind procedure; treatment duration; treatment response; viral kinetics; pathology

Citation Information

Scopus Citations: 2

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