Evaluating the Effect of Lactobacillus casei FEGY 9973 and Curcumin on Experimental Giardiasis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Shady O.M.A.; Shalash I.A.; Elshaghabee F.M.F.; Negm M.S.I.; Yousef G.A.B.; Rizk E.M.A.

Journal: Acta Parasitologica

Publisher: Springer Science and Business Media Deutschland GmbH

Publication Date: 7 December 2023

Volume / Issue: Volume 69 / Issue 1

Pages: 302–308

ISSN: 12302821

DOI: 10.1007/s11686-023-00744-4

Scopus: View on Scopus

PubMed: 38060086

Document Type: Article

Access: All Open Access; Green Open Access; Hybrid Gold Open Access

Authors and Affiliations

Shady O.M.A., Medical Parasitology Department, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt; Shalash I.A., Parasitology Department, Theodor Bilharz Research Institute, Giza, Egypt; Elshaghabee F.M.F., Department of Dairy Science, Faculty of Agriculture, Cairo University, Giza, Egypt; Negm M.S.I., Pathology Department, Faculty of Medicine, Cairo University, Giza, Egypt; Yousef G.A.B., Medical Parasitology Department, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt; Rizk E.M.A., Medical Parasitology Department, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt

Abstract

Background and Objective: Giardia is a parasitic hard protozoan that causes a variety of parasitological and pathological changes in gastrointestinal epithelial cells and is resistant to a variety of disinfectants and treatments. This study used experimental animals infected with Giardia Lamblia to assess the potential therapeutic effect of Lactobacillus casei, Lactobacillus bulgaricus (Lactobacillus in yoghurt) and curcumin in comparison to one of the commonly used drugs (metronidazole). Methods: The study included 54 Syrian hamsters (Mesocricetus auratus) that ranged in weight from 80 to 100 g and were divided into six groups: The effect of the used preparations was assessed in terms of parasitological and histopathological aspects in Group I non-infected healthy control, Group II infected non-treated, Group III infected treated with metronidazole MTZ, Group IV infected treated with Lactobacillus casei, Group V infected treated with curcumin, and Group VI infected treated with, Lactobacillus bulgaricus (Lactobacillus in yoghurt). The number of G. lamblia cysts per gram of stool was counted during the parasitological examination. Results: The difference between the infected non-treated group and all the treated groups was statistically significant (P0.05). When compared to the infected untreated group, Lactobacillus casei and, Lactobacillus bulgaricus (Lactobacillus in yoghurt) produced a 100% reduction in G. lamblia cyst shedding, curcumin produced an 87.80% reduction in number of cysts, and metronidazole produced a 78.4% reduction in number of cysts. Conclusion: Our results highlight the potentially effective therapeutic effect of different preparations of probiotics and curcumin against Giardiasis. © The Author(s) 2023.

Keywords

Curcumin; Giardiasis; Lactobacillus casei; Probiotic; Animals; Antiprotozoal Agents; Cricetinae; Disease Models, Animal; Feces; Giardia lamblia; Lacticaseibacillus casei; Mesocricetus; Metronidazole; Probiotics; antiprotozoal agent; probiotic agent; animal; disease model; drug effect; Giardia intestinalis; hamster; microbiology; parasitology

Citation Information

Scopus Citations: 6

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