Morphometric Analysis of the Changes in Glomerular Podocytes in Patients Suffereing from Proteinuria: An Ultrastructural Observational Study

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Tawfik S.H.; Abutaleb H.; Aboushousha T.; Hassan T.A.; Hafiz E.O.

Journal: Journal of Microscopy and Ultrastructure

Publisher: Wolters Kluwer Medknow Publications

Publication Date: 2 November 2023

Volume / Issue: Volume 13 / Issue 3

Pages: 157–161

ISSN: 2213879X

DOI: 10.4103/jmau.jmau_39_23

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Green Open Access; Hybrid Gold Open Access

Authors and Affiliations

Tawfik S.H., Department of Electron Microscopy, Theodor Bilharz Research Institute, Warraq Al Hadar, Egypt; Abutaleb H., Department of Emeritus of Medical Biostatistics and Demographic, Theodor Bilharz Research Institute, Warraq Al Hadar, Egypt; Aboushousha T., Department of Pathology, Theodor Bilharz Research Institute, Warraq Al Hadar, Egypt; Hassan T.A., Department of Nephrology, Theodor Bilharz Research Institute, Warraq Al Hadar, Egypt; Hafiz E.O., Department of Electron Microscopy, Theodor Bilharz Research Institute, Warraq Al Hadar, Egypt

Abstract

Background: The development of proteinuia could be found in various glomerular disorders and is much related to the pathomorphologic changes of podocytes rather than the glomerular pattern of injury. Methodology: This is an observational electron microscopic study that included fifteen archived renal core biopsies of patients suffering from proteinuria. This work gathers detailed electron microscopic measurements of the podocytes' morphologic changes and correlated them to each other and to the level of proteinuria in patients. Results: We found that the cytoskeletal change of the podocytes in the form of massive simplification and effacement (>4000 nm, as the longest dimension of a podocyte) is the leading ultrastructural feature in proteinuric patients. Conclusion: Future molecular projects would aid more in understanding the pathogenesis and management of proteinuria. © 2023 Journal of Microscopy and Ultrastructure.

Keywords

Bare Areas of the glomerular capillary basement membrane; effaced podocytes; electron microscope; proteinuria; slit diagphragm

Citation Information

Scopus Citations: 1

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