Chemo-profiling and bioactivities of Taif rose (Rosa damascena Mill.) industrial by-products after hydrodistillation

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Osman E.E.A.; Bazaid S.A.; Abdel-Hameed E.-S.S.

Journal: Journal of Applied Pharmaceutical Science

Publisher: Open Science Publishers LLP Inc.

Publication Date: 1 October 2023

Volume / Issue: Volume 13 / Issue 10

Pages: 119–131

ISSN: 22313354

DOI: 10.7324/JAPS.2023.116845

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Osman E.E.A., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Bazaid S.A., College of Sciences, Taif University, Taif, Saudi Arabia; Abdel-Hameed E.-S.S., Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

This study investigated the chemical composition of Rosa damascena Mill. (grown in the Taif region of Saudi Arabia), in relation to their potential as antioxidants and anticancer agents. The rose flowers are used to produce essential oils and hydrosol, but the process generates a significant amount of —solid and liquid. They contain biologically active compounds and can be treated as by-products. This study aimed to characterize these materials and analyze their extracts for biological activity. The total phenolic, flavonol, and flavonoid contents were quantified, and their chemical compositions were determined using liquid chromatography-mass spectrometry analysis. The antioxidant properties were estimated in vitro using three methods [1,1-diphenyl picrylhydrazyl (DPPH) radical, phosphomolybdenum, and ferric reducing power assays], while an anticancer test was carried out using the liver carcinoma cell line (HepG2). The findings showed that the texture’s n-butanol (n-BuOH) fraction had the highest overall phenolic, flavonoid, and flavonol contents (230.69 ± 10.50 mg gallic acid equivalents /g ext., 71.66 ± 3.15 mg RE/g ext., and 51.70 ± 0.61 mg QE/g ext., respectively). The liquid chromatography-electrospray ionization-mass spectrometry analysis of the by-product extracts led to identifying 55 polyphenolic compounds, including organic acids, flavonoids, phenolic acids, and tannins, of which some constituents were described in Rosa extracts for the first time. In addition, the n-BuOH fraction of the texture and wastewater had a significant DPPH radical scavenging activity with SC50s values of 7.57 ± 0.01 and 12.78 ± 0.13 μg/ml, respectively. Furthermore, the cytotoxic activity of the n-BuOH fraction of texture showed the highest activity on HepG2 (IC50 = 12.1 ± 0.85 μg/ml) followed by wastewater n-BuOH fr. (IC50 = 14.00 ± 1.05 μg/ml) and the methanolic extract of texture (IC50 = 20.5 ± 1.41 μg/ml). Our findings indicated that rose industrial by-products are enriched with polyphenolic compounds with promising antioxidants and anticancer activities. Thus, they could be used as a food supplement. © 2023 Ezzat E. A. Osman et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

Keywords

Anticancer; antioxidant; industrial wastes; phytochemicals; R. damascena; butanol; caffeic acid; carboxylic acid; quercetin; ABTS radical scavenging assay; antineoplastic activity; antioxidant activity; Article; biological activity; cell survival; chemical composition; chemical fingerprinting; column chromatography; DPPH radical scavenging assay; ferric reducing antioxidant power assay; Hep-G2 cell line; high performance liquid chromatography; human; human cell; hydrodistillation; liquid chromatography-mass spectrometry; mass fragmentography; nonhuman; oxidative stress; retention time; Rosa damascena; Saudi Arabia; solvent extraction

Citation Information

Scopus Citations: 6

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