Toxicological, hepato-renal, endocrine disruption, oxidative stress and immunohistopathological responses of chitosan capped gold nanocomposite on Biomphalaria alexandrina snails

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Ibrahim A.M.; Bekhit M.; Sokary R.; Hammam O.; Atta S.

Journal: Pesticide Biochemistry and Physiology

Publisher: Academic Press Inc.

Publication Date: September 2023

Volume / Issue: Volume 195

Article No.: 105559

ISSN: 483575

DOI: 10.1016/j.pestbp.2023.105559

Scopus: View on Scopus

PubMed: 37666595

Document Type: Article

Authors and Affiliations

Ibrahim A.M., Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt; Bekhit M., Radiation Chemistry Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt; Sokary R., Radiation Chemistry Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt; Hammam O., Pathology Department, Theodor Bilharz Research Institute, Giza, Egypt; Atta S., Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

The present investigation aimed to synthesize chitosan‑gold nanocomposites (Ch-AuNPs) with gamma radiation, then to evaluate its toxic effect on the freshwater snails Biomphalaia alexandrina. Results showed that Ch-AuNPs is spherical shaped with average size 12 nm. It had a toxic effect against B. alexandrina snails with LC50 20.43 mg/l. Exposure of B. alexandrina snails to LC10 7.51 or LC25 13.63 mg/l of Ch-AuNPs, reduced the survival, reproductive and fecundity rates; total protein and albumin; both testosterone (T) and 17β Estradiol (E) levels; SOD and CAT activities of exposed snails while increased the activities of transaminases (AST & ALT), uric acid, creatinine, TAC and MDA levels compared to the control group. Results were supported by histopathological and immunohistopathological alterations of the digestive and hermaphrodite glands. In conclusion B. alexandrina could be used as a model to screen the negative impact of nanomaterials. Also, Ch-AuNPs could be used as a molluscicidal agent. © 2023 Elsevier Inc.

Keywords

Biomphalaria alexandrina; Chitosan; Immunohistopathology; Nanoparticles; Physiological changes; Animals; Biomphalaria; Gold; Metal Nanoparticles; Nanocomposites; Oxidative Stress; metal nanoparticle; nanocomposite; animal

Citation Information

Scopus Citations: 7

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