The potential curative and hepatoprotective effects of platelet rich plasma on liver fibrosis in Schistosoma mansoni experimentally infected mice

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Bayoumi A.M.A.; Ismail M.A.M.; Mahmoud S.S.; Soliman A.S.A.; Mousa A.M.A.; Yousof H.-A.S.A.

Journal: Journal of Parasitic Diseases

Publisher: Springer

Publication Date: 3 April 2023

Volume / Issue: Volume 47 / Issue 2

Pages: 349–362

ISSN: 9717196

DOI: 10.1007/s12639-023-01576-9

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Green Open Access

Authors and Affiliations

Bayoumi A.M.A., Medical Parasitology Department, Faculty of Medicine, Damietta University, Damietta, Egypt; Ismail M.A.M., Medical Parasitology Department, Kasr Al-Ainy Faculty of Medicine, Cairo University, Kasr Al-Ainy St, Cairo, 11562, Egypt; Mahmoud S.S., Parasitology Department, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt; Soliman A.S.A., Pathology Department, National Research Centre, Cairo, Egypt; Mousa A.M.A., Pathology Department, Faculty of Medicine, October 6 University, 6th of October City, Egypt; Yousof H.-A.S.A., Medical Parasitology Department, Kasr Al-Ainy Faculty of Medicine, Cairo University, Kasr Al-Ainy St, Cairo, 11562, Egypt

Abstract

Trapped Schistosoma mansoni eggs trigger fibrotic liver disease that can continue to liver cirrhosis and failure. This work evaluates the outcome of platelet rich plasma (PRP) on S. mansoni-induced liver fibrosis by intraperitoneal (IP) and intrahepatic (IH) routes with/without Praziquantel (PZQ) treatment. Swiss albino mice (n = 162) were divided into non-infected (n = 66) and infected (n = 96) groups, then subdivided into non-treated and treated subgroups with PRP(IP), PRP(IH) 6th and 10th weeks post-infection, PZQ, PZQ + PRP(IP) and PZQ + PRP(IH) 6th and 10th weeks post-infection. Effects of treatments were evaluated by parasitological, histopathological and Immunohistochemical assessments. In the early assessment (12th week post-infection) of infected-treated groups, the mean granuloma number showed significant reduction in groups treated with PZQ + PRP (IH) 10th week, PRP (IP), PZQ + PRP (IP) and PZQ + PRP (IH) 6th week (33.33%, 33%, 27.77% and 27.22%, respectively). Furthermore, the mean granuloma diameter showed significant reduction in groups treated with PRP (IH) 10th week and PZQ + PRP (IP) (24.17% and 15.5%, respectively). Also, the fibrotic index showed significant reduction in groups treated with PZQ + PRP (IP), PRP (IP) and PZQ + PRP (IH) 6th week (48.18%, 46.81% and 41.36%, respectively). Transforming growth factor β1(TGF-β1) expression was in correlation with parasitological and histopathological results. Diminished TGF-β1 expression was mostly in infected groups treated with PZQ + PRP (IP), PZQ + PRP (IH) 6th week and PRP (IP) (88.63%, 88.63% and 77.27%, respectively). In the late assessment (14th week post-infection) of infected treated groups, TGF-β1expression was reduced in groups treated with PZQ, PRP (IH) 10th weeks, PRP (IP) (83.33%, 66.66%, 33.33% respectively). PRP showed promising anti-fibrotic effects on S. mansoni-induced liver fibrosis. © 2023, Indian Society for Parasitology.

Keywords

Liver fibrosis; Platelet rich plasma (PRP); Praziquantel (PZQ); Schistosoma mansoni; Transforming growth factor-β1 (TGF-β1); cremophor; heparin; praziquantel; thiopental; transforming growth factor beta1; animal experiment; animal model; animal tissue; Article; controlled study; granuloma; histopathology; immunohistochemistry; liver protection; liver sinusoid; male; mouse; nonhuman; outcome assessment; parasitology; protein expression; thrombocyte rich plasma

Citation Information

Scopus Citations: 6

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