Telocytes and ezrin expression in normal-appearing tissues adjacent to urothelial bladder carcinoma as predictors of invasiveness and recurrence

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Wishahi M.; Hassan S.; Hassan M.; Badawy M.; Hafiz E.

Journal: Scientific Reports

Publisher: Nature Research

Publication Date: 15 April 2023

Volume / Issue: Volume 13 / Issue 1

Article No.: 6179

ISSN: 20452322

DOI: 10.1038/s41598-023-33282-0

Scopus: View on Scopus

PubMed: 37061568

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Wishahi M., Department of Urology, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba, P.O. 30, Giza, 12411, Egypt; Hassan S., Department of Electron Microscopy, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba, P.O. 30, Giza, 12411, Egypt; Hassan M., Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt; Badawy M., Department of Urology, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba, P.O. 30, Giza, 12411, Egypt; Hafiz E., Department of Electron Microscopy, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba, P.O. 30, Giza, 12411, Egypt

Abstract

Recurrence and progression rates vary widely among different histological subtypes of bladder cancer (BC). Normal-appearing mucosa in non-muscle invasive bladder cancer and muscle-invasive bladder cancer in cystoscopy and histopathology is a factor in staging and treatment. Telocytes (TCs) are spindle-shaped cells that connect with other cell types allowing communication though cytoskeletal signaling. They are involved in tissue regeneration and pathogenesis of diseases and cancer. In this study, 12 normal-appearing tissues from urinary bladder with BC, both invasive and non-invasive were evaluated in patients who had either trans-urethral resection of bladder tumor or cystectomy. In each case, cystoscopy, intraoperative inspection, and histopathology all confirmed the absence of cancerous elements. Five patients with neurogenic bladder were used as a control group. Immunohistochemistry revealed that c-Kit + cells were intensively distributed in bladder layers from BC samples, while they were seldom detected in the control group. Ultrastructural examination of reprocessed tissue showed an intense distribution of TCs and telopodes in the submucosa and between smooth muscle cells in BC. Telopodes were numerous, arborizing, and intercommunicating. Whereas TCs and telopodes were scarce in the neurogenic bladder. Also, cancerous tissue had the highest expression level of ezrin protein, and this level gradually decreased as we moved away from the tumor. Our finding of TCs number in normal-appearing tissues in conjunction with ezrin expression may compete invasiveness and possibly a trail to reduce recurrence rates. © 2023, The Author(s).

Keywords

Carcinoma, Transitional Cell; Humans; Neoplasm Invasiveness; Telocytes; Urinary Bladder; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; ezrin; bladder; bladder tumor; human; metabolism; neurogenic bladder; pathology; telocyte; transitional cell carcinoma; tumor invasion

Citation Information

Scopus Citations: 6

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