Six Algerian plants: Phenolic profile, antioxidant, antimicrobial activities associated with different simulated gastrointestinal digestion phases and antiproliferative properties

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Er Kemal M.; Bakchiche B.; Kemal M.; Cheraif K.; Kara Y.; Bardaweel S.K.; Miguel M.G.; Yildiz O.; Ghareeb M.A.

Journal: Journal of Herbal Medicine

Publisher: Elsevier GmbH

Publication Date: March 2023

Volume / Issue: Volume 38

Article No.: 100636

ISSN: 22108033

DOI: 10.1016/j.hermed.2023.100636

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Bronze Open Access

Authors and Affiliations

Er Kemal M., Department of Food Processing, Macka Vocational High School, Karadeniz Technical University, Trabzon, Turkey; Bakchiche B., Laboratory of Process Engineering, Faculty of Technology, Amar Telidji University Laghouat, Algeria; Kemal M., Department of Nutrition & Dietetics, Faculty of Health Sciences, Artvin Coruh University, Artvin, Turkey; Cheraif K., Laboratory of Process Engineering, Faculty of Technology, Amar Telidji University Laghouat, Algeria; Kara Y., Department of Chemistry, Faculty of Science, Karadeniz Technical University, Trabzon, Turkey; Bardaweel S.K., Department of Pharmaceutical Sciences, School of Pharmacy, University of Jordan, Amman, Jordan; Miguel M.G., Faculdade de Ciências e Tecnologia, Universidade do Algarve, Mediterranean Institute for Agriculture, Environment and Development, Campus de Gambelas, Faro, 8005-139, Portugal; Yildiz O., Basic Pharmaceutical Sciences, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey; Ghareeb M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza, 12411, Egypt

Abstract

Introduction: Mediterranean countries, including Algeria, have medicinal plants used in folk medicine, such as Artemisia campestris L., Artemisia herba-alba Asso, Juniperus phoenicea L., Juniperus oxycedrus L., Mentha pulegium L., and Lavandula angustifolia Mill. It is noteworthy that the bioaccessibility of their polyphenolic ingredients have not been critically evaluated before. Methods: The bioactive properties of the aqueous extracts of Artemisia campestris L., Artemisia herba-alba Asso, Juniperus phoenicea L., Juniperus oxycedrus L., Mentha pulegium L., and Lavandula angustifolia Mill. were investigated. They were subjected to a simulated gastrointestinal digestion to evaluate the antioxidant, antimicrobial activities and total polyphenol contents. Their antiproliferative activities against three human cancer cell lines (MCF-7, T47D, and Caco-2) were also performed using the aqueous extracts. The phenolic profile was also studied by reversed-phase high-performance liquid chromatography coupled to ultraviolet spectrometry detector (RP-HPLC-UV). Results: The results indicated that bioaccessibility of total phenolic compounds after the post-gastric, intestinal, and colon phases was in the ranges of 4.34–11.57 %, 0–0.55 %, and 3.92–9.24 %, respectively when compared with their aqueous extracts. Intestinal and colon phase samples collected from intestinal digestion of six plant extracts did not have any antioxidant activity. Juniperus spp. extracts had the highest antiproliferative activity compared to the results obtained from other tested species. Conclusions: The high antioxidant and cytotoxic activities of Juniperus samples may be attributed to the higher levels of total phenols, as well as the catechins, rutin and caffeic acid, whilst M. pulegium extract with the lowest phenolic content and lower amounts of these metabolites, having p-coumaric acid as a predominant phenolic compound, was shown to be less effective as an antioxidant and anticancer agent. © 2023 Elsevier GmbH

Keywords

Algerian plants; Artemisia; Bioaccessibility; Bioactivity; In vitro digestion; Juniperus; Lavandula; Mentha; 4 hydroxybenzoic acid; antibiotic agent; antifungal agent; antineoplastic agent; antioxidant; Artemisia campestris extract; Artemisia herba alba extract; caffeic acid; catechin; chlorogenic acid; chrysin; cinnamic acid; clotrimazole; daidzein; doxorubicin; epicatechin; essential oil; ferulic acid; gallic acid; gentamicin; hesperidin; Juniperus oxycedrus extract; Juniperus phoenicea extract; Lavandula angustifolia extract; luteolin; Mentha pulegium extract; myrecetin; myricetin; para coumaric acid; phenol derivative; plant extract; polyphenol; polyphenol derivative; protocatechuic acid; resveratrol; rutoside; syringic acid; trolox C; unclassified drug; Algerian; antimicrobial activity; antioxidant activity; antiproliferative activity; aqueous solution; Artemisia campestris; Artemisia herba alba; Article; biological activity; Caco-2 cell line; clinical evaluation; colon tissue; comparative study; controlled study; cytotoxicity; digestion; gastrointestinal tract; human; human cell; intestine tissue; Juniperus oxycedrus; Juniperus phoenicea; Lavandula angustifolia; MCF-7 cell line; medicinal plant; Mentha pulegium; reversed phase high performance liquid chromatography; stomach tissue; T-47D cell line; ultraviolet spectroscopy

Citation Information

Scopus Citations: 22

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