Histopathological, Immunohistochemical, Biochemical, and In Silico Molecular Docking Study of Fungal-Mediated Selenium Oxide Nanoparticles on Biomphalaria alexandrina (Ehrenberg, 1831) Snails

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Ibrahim A.M.; Ghazy M.; El-Sayed H.; Abd El-Hameed R.M.; Khalil R.G.; Korany S.M.; Aloufi A.S.; Hammam O.A.; Morad M.Y.

Journal: Microorganisms

Publisher: MDPI

Publication Date: 22 March 2023

Volume / Issue: Volume 11 / Issue 3

Article No.: 811

ISSN: 20762607

DOI: 10.3390/microorganisms11030811

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Ibrahim A.M., Medical Malacology Department, Theodor Bilharz Research Institute, Giza, 12411, Egypt; Ghazy M., Water Pollution Research Department, National Research Centre, El Tahrir Street, Dokki, Giza, 12622, Egypt; El-Sayed H., Botany and Microbiology Department, Faculty of Science, Helwan University, Helwan, 11795, Egypt; Abd El-Hameed R.M., Botany and Microbiology Department, Faculty of Science, Helwan University, Helwan, 11795, Egypt; Khalil R.G., Immunology Division, Faculty of Science, Beni-Suef University, Beni-Suef, 62521, Egypt; Korany S.M., Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia; Aloufi A.S., Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia; Hammam O.A., Pathology Departments, Theodor Bilharz Research Institute, Giza, 12411, Egypt; Morad M.Y., Zoology and Entomology Department, Faculty of Science, Helwan University, Helwan, 11795, Egypt

Abstract

Daphnia magna and freshwater snails are used as delicate bioindicators of contaminated aquatic habitats. Due to their distinctive characteristics, selenium oxide nanoparticles (SeONPs) have received interest regarding their possible implications on aquatic environments. The current study attempted to investigate the probable mechanisms of fungal-mediated selenium nanoparticles’ ecotoxicological effects on freshwater Biomphalaria alexandrina snails and Daphnia magna. SeONPs revealed a toxicological impact on D. magna, with a half-lethal concentration (LC50) of 1.62 mg/L after 24 h and 1.08 mg/L after 48 h. Survival, fecundity, and reproductive rate were decreased in B. alexandrina snails exposed to SeONPs. Furthermore, the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were markedly elevated, while albumin and total protein levels decreased. Histopathological damage in the hermaphrodite and digestive glands was detected by light, electron microscopy, and immunohistochemistry studies. The molecular docking study revealed interactions of selenium oxide with the ALT and AST. In conclusion, B. alexandrina snails and D. magna could be employed as bioindicators of selenium nanomaterial pollution in aquatic ecosystems. This study emphasizes the possible ecological effects of releasing SeONPs into aquatic habitats, which could serve as motivation for regulatory organizations to monitor and control the use and disposal of SeONPs in industry. © 2023 by the authors.

Keywords

biochemical; Biomphalaria alexandrina; Daphnia magna; immunohistopathology; molecular docking; Penicillium chrysogenum; reproductive rate; selenium oxide nanoparticles

Citation Information

Scopus Citations: 13

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