Impact of HCV eradication following direct-acting antivirals on liver stiffness measurement: a prospective longitudinal study

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Ray A.E.; Castera L.; Al-Ashry A.; Ghali S.

Journal: Egyptian Liver Journal

Publisher: Springer Science and Business Media Deutschland GmbH

Publication Date: 16 February 2023

Volume / Issue: Volume 13 / Issue 1

Article No.: 10

ISSN: 20906218

DOI: 10.1186/s43066-023-00239-x

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Ray A.E., Department of Hepatogastroenterology, Theodor Bilharz Research Institute, Giza, 12411, Egypt; Castera L., Department of Hepatology, Beaujon Hospital, University of Paris, Clichy, 92110, France; Al-Ashry A., Department of Hepatogastroenterology, Theodor Bilharz Research Institute, Giza, 12411, Egypt; Ghali S., Department of Gastroenterology and Hepatology, Faculty of Medicine, Ain Shams University, Cairo, 11517, Egypt

Abstract

Background and study aims: Egypt has been a pioneer in implementing a nationwide HCV screening and treatment program. Assessment of liver fibrosis after HCV eradication is important. The value of liver stiffness measurement (LSM) for this purpose is still debated. The aim of this prospective longitudinal study was to assess LSM evolution after HCV eradication. Patients and methods: One-hundred and three HCV patients, treated with a standard DAA regimen (sofosbuvir/daclatasvir for 3 months), underwent LSM before and 24 weeks after the end of treatment. Patients were classified into 3 groups according to baseline LSM (Baveno VI): group 1: patients without compensated advanced chronic liver disease (cACLD) (LSM < 10 kPa); group 2: patients with suspected cACLD (LSM 10–15 kPa); and group 3: patients with likely cACLD (LSM > 15 kPa). Results: The characteristics of patients were as follows: mean age 55 ± 10 years, males 48.5%, and BMI 26.31 ± 3.33 kg/m2. All patients were Child–Pugh score A and achieved SVR at W24. A significant LSM decrease was observed at W24 compared to baseline: all patients: 5.8 vs. 8.8 kPa, p = 0.002; group 1: 4.75 vs. 6.0 kPa, p = 0.0001; group 2 11.9 vs. 12.6 kPa, p = 0.042; and group 3: 24.2 vs. 28.3 kPa, p = 0.0001. Group 1 had the highest LSM decline (23.83%), followed by group 3 (14.3%) and group 2 (8.4%). Conclusion: HCV eradication was associated with a significant LSM decrease in all groups of patients. This is likely related to improvement of fibrosis, but its relation to improvement of necro-inflammation cannot be excluded. Longer follow-up of fibrosis in these patients is needed. © 2023, The Author(s).

Keywords

Compensated advanced chronic liver disease; HCV; Liver stiffness measurement; Sofosbuvir/daclatasvir; Sustained virological response; Transient elastography

Citation Information

Scopus Citations: 2

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