The antioxidant and anti-inflammatory effects of Eremina desertorum snail mucin on experimentally induced intestinal inflammation and testicular damage

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Ibrahim A.M.; Morad M.Y.; El-Khadragy M.F.; Hammam O.A.

Journal: Bioscience Reports

Publisher: Portland Press Ltd

Publication Date: 28 October 2022

Volume / Issue: Volume 42 / Issue 10

Article No.: BSR20221020

ISSN: 1448463

DOI: 10.1042/BSR20221020

Scopus: View on Scopus

PubMed: 36124858

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Ibrahim A.M., Department of Medical Malacology, Theodor Bilharz Research Institute, Giza, Egypt; Morad M.Y., Department of Zoology and Entomology, Faculty of Science, Helwan University, Egypt; El-Khadragy M.F., Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia; Hammam O.A., Department of Pathology, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Eremina desertorum snailmucin antioxidant and anti-inflammatory effects were investigated against carbon tetrachloride (CCl4)-intestinal inflammation and testes damage. Male albino mice were intraperitoneally injected with 0.5 ml/kg b.wt of 40% CCl4, twice a week for 8 weeks. The treated groups were treated orally with mucin (after 8 weeks of CCl4 intoxication, twice a week for 4 weeks). CCl4 caused significant increases in C-reactive protein, lipid peroxidation, interleukin-2 levels and caspase-3, while decreasing the total proteins levels, activities of catalase, superoxide dismutase, and glutathione reductase contents, testosterone and 17β estradiol levels compared with the control mice. The improvements of these parameters occurred after treatment with E. desertorum mucin, where all the biochemical measurements tended to restore to the normal values. Histopathologically, CCl4 caused ulceration in the columnar mucin secreting cells that lined the ileal mucosa, partial loss of goblet cells, abnormal villous/crypt ratio, and submucosal infiltrate of the inflammatory cells. Also, sections of testis showed alterations in the developmental spermatogenic arrangement of the same seminiferous tubules, with no spermatozoa in the center. Improvements in these architectures occurred after administration of mucin, where sections showed almost normal histological structure. In conclusion, E. desertorum mucin could be used as a supplementary material as it has antioxidant and anti-inflammatory effects; besides it has low cost. © 2022 The Author(s).

Keywords

Animals; Anti-Inflammatory Agents; Antioxidants; Inflammation; Lipid Peroxidation; Male; Mice; Mucins; Oxidative Stress; Plant Extracts; Snails; Testis; C reactive protein; carbon tetrachloride; caspase 3; catalase; estradiol; glutathione reductase; interleukin 2; mucin; superoxide dismutase; testosterone; antiinflammatory agent; antioxidant; plant extract; albino mouse; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; biochemistry; cell loss; controlled study; drug effect; enteritis; enzyme activity; Eremina desertorum; goblet cell; histopathology; inflammatory cell; mouse; nonhuman; snail; testis disease; animal; metabolism

Citation Information

Scopus Citations: 11

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