Toxicity study of methanol extract of Rosa damascena trigintipetala in mice

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Sabra A.-N.A.; Bazaid S.A.; Abdel-Hameed E.-S.S.

Journal: Egyptian Journal of Chemistry

Publisher: National Information and Documentation Centre

Publication Date: 2 August 2022

Volume / Issue: Volume 66 / Issue 4

Pages: 253–264

ISSN: 4492285

DOI: 10.21608/EJCHEM.2022.146123.6358

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Sabra A.-N.A., Pharmacology Department, Theodor Bilharz Research Institute, Kornish El-Nile-Warrak El-Hadar, Imbaba, Giza, 12411, Egypt; Bazaid S.A., College of Sciences, Taif University, P. O. Box 11099, Taif, 21944, Saudi Arabia; Abdel-Hameed E.-S.S., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile-Warrak El-Hadar, Imbaba, Giza, 12411, Egypt

Abstract

Rose is one of the most important ornamental plants, with economic and cultural importance. In this work, the methanol extract of Taif rose (Rosa damascena trigintipetala Dieck) was investigated for its toxicity (Acute, Sub-chronic and Chronic) and long-term side effects. In addition, the effect of dose accumulation on physiological parameters and histopathological changes in normal mice was studied. The results of this study showed that no toxicity indication of methanol extract of Taif rose during acute, sub-chronic and chronic periods on physiological parameters while the pathological studies showed minimal changes in the vital organs. From this work, it is clear that Taif rose methanol extract could be utilised as a good natural, affordable, and safe therapy. ©2023 National Information and Documentation Center (NIDOC)

Keywords

acute; chronic toxicity; methanol extract; mice; sub-chronic; Taif Rose

Citation Information

Scopus Citations: 0

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