Assessment of circulating levels of microRNA-326, microRNA-424, and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Youssef S.S.; Elfiky A.; Nabeel M.M.; Shousha H.I.; Elbaz T.; Omran D.; Marie M.S.; Elzahry M.A.; Abul-Fotouh A.; Hashem A.; Guda M.F.; Abdelaziz A.O.

Journal: World Journal of Hepatology

Publisher: Baishideng Publishing Group Inc

Publication Date: 27 August 2022

Volume / Issue: Volume 14 / Issue 8

Pages: 1562–1575

ISSN: 19485182

DOI: 10.4254/wjh.v14.i8.1562

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Youssef S.S., Department of Microbial Biotechnology, National Research Centre, Cairo, 1211, Egypt; Elfiky A., Department of Environmental and Occupational Medicine, National Research Centre, Cairo, 1211, Egypt; Nabeel M.M., Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt; Shousha H.I., Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt; Elbaz T., Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt; Omran D., Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, 1256, Egypt; Marie M.S., Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt; Elzahry M.A., Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, 1256, Egypt; Abul-Fotouh A., Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, 1256, Egypt; Hashem A., Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, 1256, Egypt; Guda M.F., Theodor Bilharz Research Institute, Cairo, 1256, Egypt; Abdelaziz A.O., Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt

Abstract

BACKGROUND Hepatocellular carcinoma (HCC) is the fifth most common cancer. Differential expression of microRNAs (miRNAs)-326, miRNA-424, and miRNA-511 has been associated with the diagnosis and prognosis of HCC in different populations. However, limited information is available regarding their expression in Egyptian HCC patients. AIM To assess the role of circulating miRNAs-326, miRNA-424, and miRNA-511 in Egyptian HCC patients. METHODS This prospective observational study included 70 HCC patients and 25 healthy controls. The circulating levels of these three miRNAs were evaluated by real-time PCR. Receiver operating characteristic curve analysis was used to test the diagnostic accuracy of microRNA expression levels. RESULTS All miRNAs were differentially expressed in HCC patients; miRNAs326 and miRNA-424 were upregulated, while miRNA-511 was downregulated. Both miRNA-326 and miRNA-424 showed sensitivity and specificity of 97%, 71.4%, and 52%, 60%, respectively, to differentiate HCC from controls. Moreover, miRNA-326 was associated with survival and could differentiate between Child grades (A vs B); miRNA-424 significantly differentiated early vs intermediate stages of HCC; while miRNA-511 was significantly correlated with response to modified Response Evaluation Criteria in Solid Tumors (mRECIST). CONCLUSION We conclude that miRNA-326, miRNA-424, and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved

Keywords

Hepatocellular carcinoma; Mirna-424; Mirna-511; Mirnas-326; Modified response evaluation criteria in solid tumors

Citation Information

Scopus Citations: 9

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