COVID-19 and liver diseases

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Elghannam M.T.; Hassanien M.H.; Ameen Y.A.; ELattar G.M.; ELRay A.A.; Turky E.A.; ELTalkawy M.D.

Journal: Egyptian Liver Journal

Publisher: Springer Science and Business Media Deutschland GmbH

Publication Date: 21 July 2022

Volume / Issue: Volume 12 / Issue 1

Article No.: 43

ISSN: 20906218

DOI: 10.1186/s43066-022-00202-2

Scopus: View on Scopus

Document Type: Review

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Elghannam M.T., Theodor Bilharz Research Institute, Giza, Egypt; Hassanien M.H., Theodor Bilharz Research Institute, Giza, Egypt; Ameen Y.A., Theodor Bilharz Research Institute, Giza, Egypt; ELattar G.M., Theodor Bilharz Research Institute, Giza, Egypt; ELRay A.A., Theodor Bilharz Research Institute, Giza, Egypt; Turky E.A., Theodor Bilharz Research Institute, Giza, Egypt; ELTalkawy M.D., Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Coronavirus causes an outbreak of viral pneumonia that spread throughout the world. Liver injury is becoming more widely recognized as a component of the clinical picture of COVID-19 infection. Hepatitis with serum ALT elevation has been reported in up to half of patients. Patients with CLD were at a higher risk of decompensation with liver failure, hospitalization, and mortality. The percentage of acute liver injury (ALI) varied from 5 to 28%. COVID-19 hinders HCV elimination by 2030. It is recommended to continue treatment of chronic HCV and chronic HBV if already receiving treatment. Consider using antiviral therapy to prevent viral flare-ups in patients with occult or resolved HBV and COVID-19 who are receiving immunosuppressive agents. Patients with AIH do not have an increased risk of adverse outcomes even in high-risk areas. There is an association between MAFLD and disease progression. Patients with any type of cancer are at a higher risk of infection and are more likely to develop more severe clinical outcomes. Most societies advise against immunosuppressant modifications in patients with mild COVID-19, whereas in rare cases such as severe lymphopenia, worsening pneumonia, or bacterial or fungal superinfection, reduction or discontinuation of antiproliferative agents and lymphocyte-depleting therapies has been suggested. © 2022, The Author(s).

Keywords

Autoimmune liver disease; Coronaviruses; COVID-19 vaccination; Hepatocellular carcinoma; Liver diseases; Liver transplantation; SARS-CoV-2

Citation Information

Scopus Citations: 6

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