Schistosomicidal efficacy of bee venom-loaded pluronic F127 nanomicelles in S. mansoni infected CD1 mice

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Badr A.M.; Saleh A.H.; Mahmoud S.S.; Mousa M.R.; Mahana N.A.; Abo Dena A.S.

Journal: Journal of Drug Delivery Science and Technology

Publisher: Editions de Sante

Publication Date: May 2022

Volume / Issue: Volume 71

Article No.: 103344

ISSN: 17732247

DOI: 10.1016/j.jddst.2022.103344

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Badr A.M., Zoology Department, Faculty of Science, Cairo University, Giza, 12613, Egypt; Saleh A.H., Zoology Department, Faculty of Science, Cairo University, Giza, 12613, Egypt; Mahmoud S.S., Department of Parasitology, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt; Mousa M.R., Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt; Mahana N.A., Zoology Department, Faculty of Science, Cairo University, Giza, 12613, Egypt; Abo Dena A.S., Faculty of Oral and Dental Medicine, Future University in Egypt (FUE), New Cairo, Egypt, Pharmaceutical Chemistry Department, National Organization for Drug Control and Research (NODCAR), P.O. Box 29, Giza, Egypt

Abstract

This study reports a nanoformulation for avoiding the high-dose problems of bee-venom (BV) via encapsulation inside pluronic F127 (F127) nanoparticles (NPs) for treatment of schistosomiasis. After three weeks of treatment, the obtained data showed a reduction in the total worm burden, oogram pattern and ova count compared with the infected control. Moreover, the immunomodulatory functions of BV-loaded NPs were observed via stimulating the innate immune responses (IL-33), T helper (Th)-1 immunity (TNF-α) and Th-2 (IL-10). All treatments induced a reduction in the number and diameter of granuloma, while BV-loaded NPs induced the formation of new hepatic bile ductules. Both F127 NPs and BV-loaded NPs induced a significant decrease in liver fibrosis area percentage compared with the infected control. Free BV showed a limited effect on the S. mansoni larvae, while BV-loaded and plain F127 NPs showed remarkable schistosomicidal effects on the adult parasites. © 2022

Keywords

Bee venom; Pluronic F127 nanoparticles; Schistosoma mansoni; interleukin 10; interleukin 33; nanoparticle; poloxamer; tumor necrosis factor; adolescent; adult; animal cell; animal experiment; animal model; animal tissue; Article; cellular immunity; controlled study; drug delivery system; drug efficacy; drug formulation; encapsulation; female; helper cell; immunomodulation; immunonutrition; innate immunity; larva; liver fibrosis; liver granuloma; mouse; nonhuman; ovum; schistosomiasis mansoni; Th1 cell; Th2 cell; treatment duration; worm burden

Citation Information

Scopus Citations: 3

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