Multidisciplinary basic and clinical research of acute kidney injury with COVID-19: Pathophysiology, mechanisms, incidence, management and kidney transplantation

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Wishahi M.; Kamal N.M.

Journal: World Journal of Nephrology

Publisher: Baishideng Publishing Group Inc

Publication Date: 25 May 2022

Volume / Issue: Volume 11 / Issue 3

Pages: 105–114

ISSN: 22206124

DOI: 10.5527/wjn.v11.i3.105

Scopus: View on Scopus

Document Type: Short survey

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Wishahi M., Department of Urology, Theodor Bilharz Research Institute, Cairo, 12411, Egypt; Kamal N.M., Department of Anaesthesia and Surgical Intensive Care, Theodor Bilharz Research Institute, Cairo, 12411, Egypt

Abstract

Acute kidney injury (AKI) linked to coronavirus disease 2019 (COVID-19) has been identified in the course of the disease. AKI can be mild or severe and that is dependent on the presence of comorbidities and the severity of COVID-19. Among patients who had been hospitalized with COVID-19, some were admitted to intensive care unit. The etiology of AKI associated with COVID-19 is multifactorial. Prevention of severe AKI is the prime task in patients with COVID-19 that necessitates a battery of measurements and precautions in management. Patients with AKI who have needed dialysis are in an increased risk to develop chronic kidney disease (CKD) or a progression of their existing CKD. Kidney transplantation patients with COVID-19 are in need of special management to adjust the doses of immunosuppression drugs and corticosteroids to guard against graft rejection but not to suppress the immune system to place the patient at risk of developing a COVID-19 infection. Immunosuppression drugs and corticosteroids for patients who have had a kidney transplant has to be adjusted based on laboratory results and is individualized aiming at the protection of the transplanted from rejection. © The Author(s) 2022.

Keywords

Acute kidney injury; COVID-19; Cytokine storm; Dialysis; Immunosuppressant; Intensive care unit; Kidney transplantation; Mortality; SARS-CoV-2

Citation Information

Scopus Citations: 10

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