Lattice strain-, size-, and magnetic- dependent anti-Trichinella spiralis effect of Er3+ lightly doped zinc ferrite nanoparticles: In-vivo and in-vitro evaluations

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Darwish A.S.; Hussien M.S.A.; Fahmy Z.H.; Bayaumy F.E.A.

Journal: Journal of Magnetism and Magnetic Materials

Publisher: Elsevier B.V.

Publication Date: March 2022

Volume / Issue: Volume 545

Article No.: 168744

ISSN: 3048853

DOI: 10.1016/j.jmmm.2021.168744

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Darwish A.S., Chemistry Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt; Hussien M.S.A., Chemistry Department and Nanoscience Laboratory for Environmental and Biomedical Applications, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt; Fahmy Z.H., Parasitology Department, Theodor Bilharz Research Institute, P.O. Box 30, Imbaba, Cairo, Egypt; Bayaumy F.E.A., Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt

Abstract

Er-doped zinc-ferrite nanoparticles ZnFe2−xErxO4 (x = 0, 0.02, 0.06, 0.10) with diluted Er3+-doping concentrations were synthesized by coprecipitation method and subjected to structural, morphological, electrical, and magnetic investigations. Their anti-Trichinella spiralis activity was in-vivo and in-vitro examined. ZnFe1.94Er0.06O4 structure was enriched by lattice-defects compared to other nanoferrites, displaying minimum Fe-O bond-length and hopping-lengths (octahedral and tetrahedral sites). These defects were the key-advantage behind owing of ZnFe1.94Er0.06O4 nanospheres to (i) lowest particle-size (of ∼8 nm), (ii) highest magnetic-moment (∼0.11), and lowest magnetic-anisotropy (∼13.5) and coercivity (∼10.5G) with unattainable saturation-magnetization, and (iii) electrical-insulating nature. As regards, ZnFe1.94Er0.06O4 exhibits superior anti-Trichinella spiralis activity. Orally-administration of ZnFe1.94Er0.06O4 in T. spiralis infected-mice at intestinal and muscle-larvae stages showed near 100% adult-worm mortality and proficient-reduction in larval-count with marked-improvement of histological/physiological features. Anti-Trichinella spiralis activity in-vitro of ZnFe1.94Er0.06O4 showed drastic sloughing and severe destruction of worm-body. With ZnFe1.94Er0.06O4, ending of trichinellosis becomes much closer than ever before. © 2021 Elsevier B.V.

Keywords

Anti-Trichinella spiralis activity; Er-doped Zn-ferrite nanoparticles; Magnetic property; Muscle larvae; T. spiralis adult worm; ZnFe<sub>1.94</sub>Er<sub>0.06</sub>O<sub>4</sub> nanoferrite; Activation energy; Bond length; Defects; Erbium compounds; Iron compounds; Magnetic moments; Mammals; Muscle; Nanomagnetics; Particle size; Saturation magnetization; Synthesis (chemical); Zinc; Zinc compounds; Anti-trichinellum spirali activity; Er-doped; Er-doped zn-ferrite nanoparticle; Ferrite nanoparticles; Muscle larva; Nanoferrites; T spirali adult worm; Trichinella spiralis; Zinc-ferrite; Znfe1.94er0.06O4 nanoferrite; Ferrite

Citation Information

Scopus Citations: 11

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