Chemical characterization, antimicrobial, antioxidant and larvicidal activities of certain fungal extracts

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdel-Motleb A.; Ghareeb M.A.; Abdel-Aziz M.S.; El-Shazly M.A.M.

Journal: Journal of Advanced Biotechnology and Experimental Therapeutics

Publisher: Bangladesh Society for Microbiology, Immunology and Advanced Biotechnology

Publication Date: 2022

Volume / Issue: Volume 5 / Issue 3

Pages: 456–472

ISSN: 26164760

DOI: 10.5455/jabet.2022.d128

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Abdel-Motleb A., Environmental Research and Medical Malacology Division, Theodor Bilharz Research Institute, Kornish El-Nile, Warrak El-Hadar, Imbaba, Giza, 12411, Egypt; Ghareeb M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile, Warrak El-Hadar, Imbaba, Giza, 12411, Egypt; Abdel-Aziz M.S., Microbial Chemistry Department, Biotechnology Research Institute, National Research Centre, Egypt; El-Shazly M.A.M., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile, Warrak El-Hadar, Imbaba, Giza, 12411, Egypt

Abstract

Fungal extracts are considered a promising source of bioactive compounds that represent the basic core of the drug industry. This study aimed at exploring the antimicrobial, antioxidantICLE and larvicidal activities of three ethyl acetate extracts of three fungal isolates Fusarium oxysporum, Aspergillus fumigatus and Penicilluim griseofulvum. These fungi were isolated from sediment samples collected in water courses of three Egyptian governorates; Giza, Qalubeya and Gharbeya, during a year from January to December 2019, molecularly identified using 18Sr RNA technique and were grown on rice medium for 14 days and extracted with ethyl acetate. GC-MS examination of the extracts led to identification of 15, 29 and 24 compounds, respectively. Hexadecanoic acid was detected as a main component in the investigated extracts. Moreover, in Folin-Ciocalteu’s assay, the tested fungal extracts showed noticeable total phenolic contents (TPCs) values of 115.84, 88.24 and 73.22, respectively for Aspergillus fumigatus, Penicillium griseofulvum and Fusarium oxysporum. Additionally, Aspergillus fumigatus extract exhibited strong total antioxidant capacity (TAC) value of 409.46 mg AAE/g dry extract, followed by Penicillium griseofulvum and Fusarium oxysporum extracts with TAC values of 299.28 and 281.31 mg AAE/g dry extract, respectively. All extracts exhibited antimicrobial activities against Staphylococcus aureus (G+ve bacterium), Escherichia coli (G-ve bacterium), Candida albicans (yeast) and Aspergillus niger (Fungus). Also, the extracts showed high larvicidal activity against miracidia and cercariae of Schistosoma mansoni. In conclusion, Fusarium oxysporum, Aspergillus fumigatus and Penicilluim griseofulvum are excellent sources of bioactive compounds which have multiple biological effects. © 2022, Bangladesh Society for Microbiology, Immunology and Advanced Biotechnology. All rights reserved.

Keywords

Antimicrobial; Antioxidant; Aspergillus; Fusarium; Larvicidal; Penicilluim

Citation Information

Scopus Citations: 10

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