The ameliorative effects of Eremina desertorum snail mucin in combination with Silymarin against experimentally induced liver fibrosis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Ibrahim A.M.; Hussein T.M.; Abdel-Tawab H.; Hammam O.A.; Ghareeb M.A.

Journal: Egyptian Journal of Chemistry

Publisher: NIDOC (Nat.Inform.Document.Centre)

Publication Date: 8 August 2021

Volume / Issue: Volume 65 / Issue 2

Pages: 181–190

ISSN: 4492285

DOI: 10.21608/EJCHEM.2021.84043.4114

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Bronze Open Access

Authors and Affiliations

Ibrahim A.M., Environmental Research and Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt; Hussein T.M., National organization for drug control and research, Cairo, Egypt; Abdel-Tawab H., Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt; Hammam O.A., Pathology Departments, Theodor Bilharz Research Institute, Giza, Egypt; Ghareeb M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza, 12411, Egypt

Abstract

Mucin is known by its biological and pharmacological activities. The aim of current study is to evaluate the hepatoprotective and the antioxidant activities of mucin extracted from Eremina desertorum snail as well as chemical profiling using GC-MS/MS analysis. This investigation confirmed the hepatoprotective and the antioxidant effects of mucin either alone or in combination with Silymarin on carbon tetrachloride (CCl4) liver damage. Male albino mice were injected intraperitoneally with 0.5ml /kg b.wt of 40% CCl4, twice/week for 8 weeks. The treated groups treated orally with Mucin (after 8 weeks of CCl4 intoxication, twice a week for four weeks) or Silymarin (from the first day of the experiment with a dose of 140 mg/kg, three times/week until the sacrifice day). After 12 weeks, all animals were sacrificed by cervical dislocation. Results showed that CCl4 induced a hepatotoxic effect represented in increasing liver enzymes, MDA and IL-2 while decreasing total protein, albumin, CAT, SOD and GSH. Amelioration in these parameters occurred after treatment of CCl4 intoxicated mice with either Silymarin or E. desertorum mucin where they caused increases in the activity of the antioxidant parameters while, reduced the level of MDA and liver enzymes activity. Also, the histopathological alterations that caused by CCl4 were improved after the treatment with this extract. GC-MS/MS analyses led to the identification of ten compounds were categorized as monoterpenes, sesquiterpenes, quinolines, and fatty acid esters. Conclusively, E. desertorum mucin enhanced antioxidant activity and ameliorated the CCl4-induced liver damage and it could be used as a hepatoprotective agent. ©2022 National Information and Documentation Center (NIDOC)

Keywords

Antioxidant; Eremina desertorum; GC-MS/MS; Hepatoprotective activity; Mucin

Citation Information

Scopus Citations: 12

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