The therapeutic role of thymoquinone bioactive compound as target natural product from nigella sativa loaded with chitosan nanoparticles on schistosomiasis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: El-Menyawy H.M.; Metwally K.M.; Aly I.R.; Abo Elqasem A.A.; Youssef A.A.

Journal: Egyptian Journal of Hospital Medicine

Publisher: Ain Shams University Faculty of Medicine

Publication Date: 1 July 2021

Volume / Issue: Volume 84 / Issue 1

Pages: 1818–1826

Article No.: 30

ISSN: 16872002

DOI: 10.21608/ejhm.2021.177604

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

El-Menyawy H.M., Zoology Department, Faculty of Science, Al-Azhar University (Girls branch), Cairo, Egypt; Metwally K.M., Zoology Department, Faculty of Science, Al-Azhar University (Girls branch), Cairo, Egypt; Aly I.R., Zoology Department, Faculty of Science, Al-Azhar University (Girls branch), Cairo, Egypt; Abo Elqasem A.A., Zoology Department, Faculty of Science, Al-Azhar University (Girls branch), Cairo, Egypt; Youssef A.A., Environmental Research and Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Background: Schistosoma mansoni is a trematode helminth responsible for liver fibrosis or cirrhosis. Aim of the work: In the present work natural products Thymoquinone loaded with chitosan nanoparticle (TQ/ChNP)) (TQ/ChNP) were used to determine their therapeutic effect on S. mansoni infection. Materials and methods: A total of 40 healthy Swiss albino mice, 20-25 g in weight, procured from Theodor Bilharz Research Institute (TBRI) Imbaba, Egypt's Schistosome Biological Supply Center (SBSC). Results: The infected mice treated with TQ/ChNP showed a significant decrease in the total worm burden. Treatment with TQ/ChNP had a highly significant effect on mature worm burden, TQ/ChNP in prophylactic and therapeutic doses significantly increased the mean number of dead ova in comparison to control. TQ/ChNP had a high decrease effect on ova count in intestinal tissue and a moderate reduction on ova count in hepatic tissue. Prophylactic dose gave a high reduction effect on ova count in intestinal tissue. As regards the size of hepatic granuloma, TQ/ChNP had the highest significant reduction on mean granuloma diameter with noticeable improvement of hepatic pathology. TQ/ChNP treated group showed observable improvement of liver pathology with mild degeneration and slight-sized fibrocellular. Conclusion: Based on the outcome of this study, TQ/ChNP proved to have potential bioactivity against S. mansoni adult stages and its potentiality in improving hepatic pathology. Efficacy of TQ/ChNP to postpone progression in chronic liver diseases must be considered as preventive medicine in patients with hepatic disorders. © 2021, Ain Shams University Faculty of Medicine. All rights reserved.

Keywords

(TQ/ChNP); Chitosan; Granuloma formation; Nigella sativa; Oogram; S. mansoni infection

Citation Information

Scopus Citations: 6

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