Phytochemical investigation and differential effects of cestrum elegans isolated compounds as antimicrobial and virucidal against Hepatitis A virus

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Nasr S.M.; Elwan N.M.; Mohamed M.A.; Abdel-Aziz A.-W.A.; Ghareeb M.A.

Journal: Egyptian Journal of Chemistry

Publisher: NIDOC (Nat.Inform.Document.Centre)

Publication Date: 8 June 2021

Volume / Issue: Volume 64 / Issue 7

Pages: 3729–3738

ISSN: 4492285

DOI: 10.21608/ejchem.2021.71934.3581

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Bronze Open Access

Authors and Affiliations

Nasr S.M., Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Cairo University, Giza, Egypt; Elwan N.M., Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt; Mohamed M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza, 12411, Egypt; Abdel-Aziz A.-W.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza, 12411, Egypt; Ghareeb M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza, 12411, Egypt

Abstract

A new steroidal saponin, named as (25R)-6α-[(β-D-glucopyranosyl) oxy]-5α-spirostan-3β-yl β-D-glucopyranosyl (1''→3')-O-β-D-glucopyranosid (2) was isolated from the flowers of Cestrum elegans. In addition, a known steroidal saponin (1), a flavonoid compound (3) along with a triterpene saponin (4) were isolated for the first time in genus Cestrum and identified based on their chromatographic properties, chemical and spectral data (HR-ESI-MS, 1H, 13C NMR, 1H-1H COSY, HSQC, and HMBC). The four compounds were evaluated for their antibacterial, antifungal and antiviral activities. The maximum non-toxic concentration (MNTC) on vero cell line was 1.56 µg/mL for all compounds. While, compound 1 and 3 showed antiviral activity of 34.3% and 25%, respectively. © 2021 National Information and Documentation Center (NIDOC)

Keywords

Antimicrobial; Antiviral; Cestrum elegans; Cytotoxicity; Steroidal saponin

Citation Information

Scopus Citations: 7

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