High-performance liquid chromatography-fingerprint analyses, in vitro cytotoxicity, antimicrobial and antioxidant activities of the extracts of Ceiba speciosa growing in Egypt

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Abdel-Aziz A.-W.A.; Elwan N.M.; Abdallah M.A.; Shaaban R.; Mohamed N.S.; Mohamed M.A.

Journal: Egyptian Journal of Chemistry

Publisher: NIDOC (Nat.Inform.Document.Centre)

Publication Date: 1 April 2021

Volume / Issue: Volume 64 / Issue 4

Pages: 1831–1843

ISSN: 4492285

DOI: 10.21608/EJCHEM.2021.58716.3267

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Bronze Open Access

Authors and Affiliations

Abdel-Aziz A.-W.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, 12411 Warrak El-Hadar, Imbaba, P.O. 30, Egypt; Elwan N.M., Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt; Abdallah M.A., Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt; Shaaban R., Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Kornaish El-Nile, 12411 Warrak El-Hadar, Imbaba, P.O. 30, Egypt; Mohamed N.S., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, 12411 Warrak El-Hadar, Imbaba, P.O. 30, Egypt; Mohamed M.A., Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, 12411 Warrak El-Hadar, Imbaba, P.O. 30, Egypt

Abstract

Background: Cancer diseases and microbial resistance are serious health diseases related to oxidative stress and infectious diseases. The risk can be reduced by using plants rich in polyphenols. Methodology: Different solvent extracts from leaves of Ceiba speciosa (C.s) were evaluated for their biological and chemical activities. Also, the chemical profiles were investigated via high-performance liquid-chromatography (HPLC) -fingerprint analyses. Results: the leaves from Ceiba speciosa collected from the Zoo garden in Egypt, showed a moderate cytotoxicity against HepG2 in extracts; petroleum ether, ethyl acetate, dichloromethane, while weak-cytotoxicity in butanol, methanol extracts and non-cytotoxicity in water extract. Moreover, high antimicrobial activities were showed within dichloromethane, petroleum ether extracts, while a moderate antimicrobial activities were showed in methanol, ethyl acetate extracts, and low antimicrobial activities were showed in both of butanol and water extracts. On the other side, a strong antioxidant activities were recorded within extracts; dichloromethane and methanol while the least antioxidant activity was recorded within water extract. High-performance liquid-chromatography (HPLC) -fingerprint analyses is done for all fractions, this finding provides an insight into the usage of the tested species as a source of naturally occurring cytotoxic, antimicrobial and antioxidant agents. © 2021 National Information and Documentation Center (NIDOC)

Keywords

Antimicrobial; Antioxidant (DPPH); Bombacae; Ceiba speciosa; Cytotoxicity; High-performance liquid chromatography-fingerprint analyses

Citation Information

Scopus Citations: 20

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