Serum anandamide level as a potential indicator for nonalcoholic fatty liver disease severity

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Ramadan A.; Khalaf A.R.; El Ray A.; Saad Y.

Journal: European Journal of Gastroenterology and Hepatology

Publisher: Lippincott Williams and Wilkins

Publication Date: 12 March 2021

Volume / Issue: Volume 33 / Issue 1

Pages: E363–E367

ISSN: 0954691X

DOI: 10.1097/MEG.0000000000002092

Scopus: View on Scopus

PubMed: 33731590

Document Type: Article

Authors and Affiliations

Ramadan A., Department of Endemic Medicine and Hepato-Gastroenterology, Faculty of Medicine, Cairo University, Egypt; Khalaf A.R., Endemic Medicine Department-of 6th October University; El Ray A., Endemic Medicine Department-of 6th October University, Hepatogastroenterology Department Theodor Bilharz Research Institute, Giza, Egypt; Saad Y., Department of Endemic Medicine and Hepato-Gastroenterology, Faculty of Medicine, Cairo University, Egypt

Abstract

Introduction and aim Nonalcoholic fatty liver disease (NAFLD) is a very common disease, ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) and is considered the hepatic expression of metabolic syndrome. Liver biopsy is currently considered the gold standard in diagnosis of NAFLD; however, it is an invasive technique and carries many risks. The serum anandamide level is recently discovered to play an important role as the potential indicator for NAFLD severity. The purpose of the study is to determine the association of endocannabinoid metabolite anandamide and NAFLD severity and to investigate its association with anthropometric and metabolic features in NAFLD patients. Methodology A case-control study on 36 NAFLD biopsy-proven NAFLD patients and 15 healthy volunteers. They were subjected to full clinical history and examination, laboratory tests, abdominal ultrasound and serological testing of anadamide. Results The anadamide level was significantly higher among NAFLD subgroups (simple steatosis and NASH) vs. the normal group (1.1, 0.29 vs. 0.2 P value = 0.00085), with cutoff 0.58 in the NASH group (accuracy 89%; sensitivity 66% and specificity 100%) (P value < 0.01). Conclusion Anandamide could be a specific serum marker for NASH and can be used to detect NAFLD severity. © 2021 Lippincott Williams and Wilkins. All rights reserved.

Keywords

Anandamide level; liver biopsy; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; Arachidonic Acids; Case-Control Studies; Endocannabinoids; Humans; Liver; Non-alcoholic Fatty Liver Disease; Polyunsaturated Alkamides; Predictive Value of Tests; amide; anandamide; arachidonic acid derivative; endocannabinoid; case control study; complication; human; metabolism; nonalcoholic fatty liver; pathology; predictive value

Citation Information

Scopus Citations: 3

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