Neurotoxicity and genotoxicity of the veterinary antibiotics oxytetracycline and trimethoprim-sulphadiazine to Biomphalaria alexandrina snails

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Saleh H.A.; Abdel-Motleb A.; Habib M.R.

Journal: International Journal of Environmental Studies

Publisher: Routledge

Publication Date: 2 March 2021

Volume / Issue: Volume 78 / Issue 6

Pages: 983–1002

ISSN: 207233

DOI: 10.1080/00207233.2021.1893487

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Saleh H.A., Environmental Research and Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt; Abdel-Motleb A., Environmental Research and Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt; Habib M.R., Environmental Research and Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

There is increased concern about aquatic contamination with veterinary antibiotics (VAs) residues. The present study tested the effects of two commonly used antimicrobials in animal husbandry, oxytetracycline (OTC) and trimethoprim-sulphadiazine (TMS), on survival rate, DNA integrity and some biochemical parameters in the nervous system and reproductive tissues of Biomphalaria alexandrina snails as bio-indicator organisms for VAs toxicity. The results showed that both antibiotics caused a decline in the survival of snails in a dose-dependent manner. Moreover, disturbances in the levels of lipid peroxidation (MDA), antioxidant enzymes, acetylcholinesterase (AChE), and neurotransmitters were recorded in exposed snails with an overall decrease in these parameters compared to controls. In addition, comet assay revealed DNA damage in snails’ tissues following 96 h exposure. Thus, B. alexandrina snail can be used as a bio-indicator for assessing VAs toxicity and its potential impacts on the nervous system and reproduction of animals. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

bioindicator; Biomphalaria alexandrina; genotoxicity; neurotoxicity; veterinary antibiotics; Antibiotics; Cell proliferation; Histology; Tissue; Toxicity; Acetylcholinesterase; Antioxidant enzyme; Biochemical parameters; Dose-dependent manner; Lipid peroxidation; Oxytetracyclines (OTC); Reproductive tissues; Veterinary antibiotic; Molluscs

Citation Information

Scopus Citations: 4

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