Association between TNF-α, Interleukin-18 Polymorphisms and Risk of Hepatocellular Carcinoma in Egyptian patients

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Sharafelldin H.; Mors A.; Elghobary H.; Osman E.; Rady N.

Journal: Asian Pacific Journal of Cancer Prevention

Publisher: Asian Pacific Organization for Cancer Prevention

Publication Date: 1 March 2021

Volume / Issue: Volume 22 / Issue 3

Pages: 887–891

ISSN: 15137368

DOI: 10.31557/APJCP.2021.22.3.887

Scopus: View on Scopus

PubMed: 33773554

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Sharafelldin H., Clinical and Chemical Pathology, Cairo University, Cairo, Egypt; Mors A., Clinical and Chemical Pathology, Theodor Bilharz Research Institute, Cairo, Egypt; Elghobary H., Clinical and Chemical Pathology, Cairo University, Cairo, Egypt; Osman E., Clinical and Chemical Pathology, Theodor Bilharz Research Institute, Cairo, Egypt; Rady N., Clinical and Chemical Pathology, Cairo University, Cairo, Egypt

Abstract

Objective: To evaluate the association of gene polymorphisms of the SNP of TNF-α gene -238G>A and IL-18 gene-607C>A with the development of hepatocellular carcinoma among Egyptian patients. Methods: One hundred and fifty patients were allocated to this study; eighty patients with hepatocellular carcinoma (Group A), seventy cancer-free HCV age, and sex-matched patients (Group B). We analyzed two Single nucleotide polymorphisms (SNPs) (TNF-α-238G>A and IL-18-607C>A) by real-time polymerase chain reaction using sequence-specific primers (PCR-SSP). Results: Significant higher risk of HCC was associated with genotype IL-18–607AA (P<0.001), OR: 5(2.188-11.47), allele IL-18 -607⁄A (P=0.001), OR: 2.1(1.32-3.3). A significant association was found between the size of HFL in the HCC group and different genotypes of IL18 genes (P=0.013) where 62.5% of patients with tumor size >5 cm carried the risky (AA) genotype on the other hand the SNP of TNF-α gene -238G>A showed no statistically significant association between the two groups. Conclusion: The SNP -607C>A in the IL18 gene was associated with increased HCC risk in Egyptian patients suggesting its use as a potential diagnostic non-invasive tool that allows to identify a new group of HCC patients at an earlier stage. © 2021. All Rights Reserved.

Keywords

18-polymorphisms; HCC-interleukin; SNP-real time PCR; TNF-α; Aged; Carcinoma, Hepatocellular; Case-Control Studies; Egypt; Female; Genetic Predisposition to Disease; Hepatitis C, Chronic; Humans; Interleukin-18; Liver Neoplasms; Male; Middle Aged; Tumor Necrosis Factor-alpha; IL18 protein, human; interleukin 18; TNF protein, human; tumor necrosis factor; case control study; chronic hepatitis C; genetic predisposition; genetics; human; liver cell carcinoma; liver tumor

Citation Information

Scopus Citations: 5

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