The Protective Role of Toll-Like Receptor Agonist Monophosphoryl Lipid A Against Vaccinated Murine Schistosomiasis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Aly I.; Ibrahim E.H.; Hamad R.S.; Sayed H.E.L.; Attiyah S.M.N.; E-Komy W.; Ghramh H.A.; Alshehri A.; Alsyaad K.M.; Alshehri M.; Kilany M.; Morsy K.; El-kott A.F.; Taha R.

Journal: Acta Parasitologica

Publisher: Springer Science and Business Media Deutschland GmbH

Publication Date: 2 April 2020

Volume / Issue: Volume 65 / Issue 3

Pages: 652–660

ISSN: 12302821

DOI: 10.2478/s11686-020-00204-3

Scopus: View on Scopus

PubMed: 32240492

Document Type: Retracted

Authors and Affiliations

Aly I., Parasitology Laboratory, Theodor Bilharz Research Institute, Giza, Egypt; Ibrahim E.H., Biology Department, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia, Research Center for Advanced Materials Science (RCAMS), King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia, Blood Products Quality Control and Research Department, National Organization for Research and Control of Biologicals, Cairo, Egypt; Hamad R.S., Biological Sciences Department, King Faisal University, Al-Ahsa, Saudi Arabia; Sayed H.E.L., Immunology and Parasitology, Biology Department, Faculty of Sciences and Artis-Alkamel, Jeddah University, Jeddah, Saudi Arabia; Attiyah S.M.N., Immunology and Cardiology, Biology Department, Faculty of Sciences and Artis-Alkamel, Jeddah University, Jeddah, Saudi Arabia; E-Komy W., Parasitology Laboratory, Theodor Bilharz Research Institute, Giza, Egypt; Ghramh H.A., Biology Department, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia, Research Center for Advanced Materials Science (RCAMS), King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia, Unit of Bee Research and Honey Production, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia; Alshehri A., Biology Department, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia; Alsyaad K.M., Biology Department, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia; Alshehri M., Biology Department, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia; Kilany M., Research Center for Advanced Materials Science (RCAMS), King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia, Department of Microbiology, National Organization for Drug Control and Research (NODCAR), Cairo, Egypt; Morsy K., Biology Department, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia, Department of Zoology, Faculty of Science, Cairo University, Cairo, 12613, Egypt; El-kott A.F., Biology Department, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia, Department of Zoology, Faculty of Science, Damanhour University, Damanhour, Egypt; Taha R., Biology Department, Faculty of Science, King Khalid University, PO Box 9004, Abha, 61413, Saudi Arabia, Department of Clinical Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Abstract

Purpose: Schistosomiasis is a disease that afflicts over 220 million people worldwide. To date, there is no vaccine against schistosomiasis and chemotherapy relies basically on a single drug, praziquantel. The current study was undertaken to investigate the therapeutic effects of monophosphoryl lipid A (MPLA) as an adjuvant in soluble egg antigen (SEA)-vaccinated and Schistosoma mansoni-infected mice. Methods: Mice were divided into two groups of uninfected and Schistosoma mansoni infected. The two groups were treated differently with MPLA, SEA and praziquantel. Study parameters included parasitological, immunological and biochemical parameters. Results: Parasitological parameters revealed that intraperitoneal injection of MPLA into SEA-vaccinated and S. mansoni-infected mice was effective in reducing the worm and egg burden, granuloma count and diameter as well as the total area of infection in their livers versus SEA-untreated but infected ones. In addition, MPLA showed ameliorative action on the elevated liver oxidative stress marker, including malondialdehyde (MDA) and a decrease in the level of the antioxidant enzymes, reduced glutathione (GSH) and catalase (CAT) which may have a role in the liver damage and fibrosis due to S. mansoni infection. Conclusion: Treatment with MPLA has multi-functions in attenuating the deleterious impacts of S. mansoni infection in mice livers. Its effects are mediated through a reduction of ova count, worm burden, granuloma diameter and amelioration of antioxidant defense systems, and liver function biomarkers. © 2020, Witold Stefański Institute of Parasitology, Polish Academy of Sciences.

Keywords

Antioxidant enzymes; Chemotherapy; Monophosphoryl lipid A (MPLA); Oxidative stress; Schistosomiasis; SEA; Adjuvants, Immunologic; Animals; Anthelmintics; Antigens, Helminth; Helminth Proteins; Lipid A; Male; Mice; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni; Toll-Like Receptors; Vaccination; anthelmintic agent; gp50 protein, Schistosoma; helminth protein; immunological adjuvant; lapretolimod; parasite antigen; toll like receptor; animal; immunology; mouse

Citation Information

Scopus Citations: 1

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