Small-bowel mucosal changes in Egyptian cirrhotic patients with portal hypertension using capsule endoscopy versus single-balloon enteroscopy

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Saad Z.M.; El-Dahrouty A.H.; El-Sayed A.M.; Keryakos H.K.H.; Fanous N.N.; Mostafa I.

Journal: Egyptian Liver Journal

Publisher: Springer

Publication Date: 22 April 2020

Volume / Issue: Volume 10 / Issue 1

Article No.: 12

ISSN: 20906218

DOI: 10.1186/s43066-020-00025-z

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Saad Z.M., Department of Tropical Medicine; Faculty of Medicine, Minia University, Aswan-Cairo Agricultural Road, El-Minya, 61111, Egypt; El-Dahrouty A.H., Department of Tropical Medicine; Faculty of Medicine, Minia University, Aswan-Cairo Agricultural Road, El-Minya, 61111, Egypt; El-Sayed A.M., Department of Tropical Medicine; Faculty of Medicine, Minia University, Aswan-Cairo Agricultural Road, El-Minya, 61111, Egypt; Keryakos H.K.H., Department of Internal Medicine; Faculty of Medicine, Minia University, Minya, Egypt; Fanous N.N., Police Authority Hospital Agouza, Giza, Egypt; Mostafa I., Department of Gastroenterology and Endoscopy, Theodor Bilharz Research Institute (TBRI), Cairo, Egypt

Abstract

Background: Small-bowel mucosal abnormalities that may occur secondary to portal hypertension in patients with liver cirrhosis have an impact on health and quality of life. In spite of the importance of these changes, little is known about the frequency and features of small-bowel changes in cirrhotic patients with portal hypertension. Eighty cirrhotic patients with or without esophageal or gastric varices were recruited in this study as well as 60 age- and sex-matched controls. All study participants underwent capsule endoscopy. In addition, half of the patients and controls were randomized to receive single-balloon enteroscopy. Results: The prevalence of small-bowel mucosal changes was statistically significantly higher in cirrhotic patients than in controls; 57% versus 6.7%, respectively (p < 0.05). Cirrhotic patients with portal hypertensive gastropathy showed a significant increase in the small-bowel changes (p < 0.001). Small-bowel changes were significantly higher in patients with higher MELD and Child-Pugh scores (p < 0.001). Moreover, capsule endoscopy was more effective in the detection of small-bowel changes than single-balloon enteroscopy. Conclusions: Mucosal changes associated with portal hypertensive enteropathy are more prevalent in cirrhotic patients, regardless of the presence or absence of gastric varices. Small-bowel mucosal changes in patients with portal hypertensive enteropathy were more common in patients who suffered from portal hypertensive gastropathy and were positively correlated with advanced chronic liver disease. © 2020, The Author(s).

Keywords

Balloon enteroscopy; Capsule endoscopy; Cirrhosis; Portal hypertension; Small bowel

Citation Information

Scopus Citations: 2

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