Study the synergistic Effect between Nanoparticles and Spiramycin on Immunological Response Against Toxoplasmosis

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Hamad H.K.; Ramadan N.F.; Mohamed S.H.; Aly I.; Zalat R.

Journal: IOP Conference Series: Materials Science and Engineering

Publisher: Institute of Physics Publishing

Publication Date: 1 January 2020

Volume / Issue: Volume 736 / Issue 2

Article No.: 22091

ISSN: 17578981

DOI: 10.1088/1757-899X/736/2/022091

Scopus: View on Scopus

Document Type: Conference paper

Access: All Open Access; Gold Open Access

Authors and Affiliations

Hamad H.K., Biology Department, College of Science for Women- University of Baghdad, Iraq; Ramadan N.F., Zoology Department, Faculty of Science, Ain Shams University, Egypt; Mohamed S.H., Zoology Department, Faculty of Science, Ain Shams University, Egypt; Aly I., Parasitology Department, Theodor Bilharz Research Institute, Egypt; Zalat R., Parasitology Department, Theodor Bilharz Research Institute, Egypt

Abstract

This investigation was carried out to estimate the antiparasitic potential of silver and Chitosan nanoparticles loaded with spiramycin against toxoplasmosis infected. After mice injected intraperitoneal in a dose 103 viable tachyzoites for acute infection; then treated with spiramycin, chitosan nanoparticles and silver nanoparticles as a single or combined therapy given for seven days. Peritoneal fluid examination revealed a significant decrease in the number of T. gondii tachyzoites in all treated infected mice compared with infected non-treated. The combined therapy presented better results than the single one. The best effect was observed in a group of mice treated with the combined chitosan nanoparticles and silver nanoparticles loaded with spiramycin. Also, immunological parameters IgM antibody, INF-γ and TNF-α cytokines responses against T. gondii antigens were assessed in serum samples by enzyme-linked immunosorbent assays (ELISA) kits after treatment. The current work is the first time of using Ag NPs and CS NPs loaded with spiramycin as therapeutic agents against experimental toxoplasmosis. It was shown that the highest degree of effectiveness attained by the synergistic action of chitosan and Ag NPs as was indicated by lower parasite count and IFN-γ, TNF-α concentration. © Published under licence by IOP Publishing Ltd.

Citation Information

Scopus Citations: 5

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