Phenolic profiling and anti-Alzheimer’s evaluation of Eremobium aegyptiacum

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Marzouk M.M.; Ibrahim L.F.; El-Hagrassi A.M.; Fayed D.B.; Elkhateeb A.; Abdel-Hameed E.-S.S.; Hussein S.R.

Journal: Advances in Traditional Medicine

Publisher: Springer

Publication Date: 6 January 2020

Volume / Issue: Volume 20 / Issue 2

Pages: 233–241

ISSN: 26624052

DOI: 10.1007/s13596-019-00408-7

Scopus: View on Scopus

Document Type: Article

Authors and Affiliations

Marzouk M.M., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt; Ibrahim L.F., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt; El-Hagrassi A.M., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt; Fayed D.B., Department of Therapeutic Chemistry, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt; Elkhateeb A., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt; Abdel-Hameed E.-S.S., Laboratory of Medicinal Chemistry, Theodor Bilharz Institute, Giza, Egypt; Hussein S.R., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt

Abstract

The Eremobium aegyptiacum (Spreng.) Schweinf.et Asch.ex Boiss aqueous extract (EAAE) was subjected to phytochemical investigation using LC–ESI–MS analysis. Twenty-seven compounds (one organic acid, two phenolic acids and twenty-four flavonoids) were characterized and tentatively identified. Among the detected compounds, acyl triglycoside derivatives of kaempferol and isorhamnetin are identified in the current study by using LC–MS technique for the first time from this species. EAAE was evaluated for its anti-Alzheimer activity. EAAE dose (156 mg/kg bw/day) was administrated for 6 weeks orally to female adult rats prior treated with AlCl3 (50 mg/Kg b.wt) to induce Alzheimer disease. AChE level, lipid profile (TC, TG and LDL-C) levels, reduced glutathione (GSH) and malondialdehyde (MDA) levels were investigated. EAAE exhibited significant reduction in AChE level (58.57 ± 9 µMSH/min/mg protein) in comparison with AlCl3 group (97.88 ± 9.87 µMSH/min/mg protein). Also, GSH level was increased to 100.09 ± 25.51 mg/g tissue and MDA level was decreased to 1.26 ± 0.1 µmol/g tissue, compared to AlCl3 rats (57.05 ± 12.56 mg/g tissue and 1.96 ± 0.29 µmol/g tissue, respectively). Additionally, lipid profile (TC, TG, LDL-C) levels were significantly reduced to 35.15 ± 4.74, 18.16 ± 3.07 and 35.75 ± 4.17 µmol/g tissue, in comparison with AlCl3 group (65.20 ± 5.54, 27.93 ± 3.51 and 63.84 ± 6.98, respectively). Briefly, EAAE succeeded in amelioration of the increased AChE activity and the antioxidant activity which considered as an important defense mechanism to control the brain injury in AlCl3 rats. This amelioration was parallel to its effect on total cholesterol triglycerides and LDL levels. © 2020, Institute of Korean Medicine, Kyung Hee University.

Keywords

Acylated flavonoids; Anti-Alzheimer; Eremobium aegyptiacum; LC–ESI–MS; acetylcholinesterase; acyl triglycoside derivative; antioxidant; carboxylic acid derivative; Eremobium aegyptiacum extract; flavonoid; glutathione; isorhamnetin derivative; kaempferol derivative; low density lipoprotein cholesterol; malonaldehyde; phenol derivative; plant extract; plant medicinal product; triacylglycerol; unclassified drug; water; adult; Alzheimer disease; animal experiment; animal model; antioxidant activity; Article; controlled study; drug identification; drug screening; female; liquid chromatography-mass spectrometry; medicinal plant; nonhuman; priority journal; rat

Citation Information

Scopus Citations: 15

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